Recent advances in molecular endocrinology have significantly increased our understanding of endocrine diseases, as well as that of the medical management of these complicated disorders. In Developmental Endocrinology: From Research to Clinical Practice, leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of these diseases. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and, in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations- the basic processes governing prenatal development of the individual endocrine organs--and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders.
Authoritative, comprehensive, and readily accessible, Developmental Endocrinology: From Research to Clinical Practice illuminates for today's medical investigators, basic scientists, and clinicians our rapidly emerging understanding of this complex field, as well as constituting an invaluable guide to the practical clinical management of endocrine diseases.

Klappentext

Leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of endocrine disease. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations-the basic processes governing prenatal development of the individual endocrine organs-and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders.

Inhalt

Part I. Hypothalamus/Pituitary Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis Gretchen E. Parker, Kyle W. Sloop, and Simon J. Rhodes Part II. Growth Molecular Mutations in the Human Growth Hormone Axis Zvi Laron Normal and Abnormal Growth Emily C. Walvoord and Erica A. Eugster Adult Growth Hormone Deficiency Zehra Haider and James W. Edmondson Part III. Thyroid Molecular Mechanisms of Thyroid Gland Development: Insights from Clinical Studies and from Mutant Mice Guy Van Vliet Fetal-Perinatal Thyroid Physiology Delbert A. Fisher Thyroid Disorders in Children and Adolescents Scott A. Rivkees Part IV. Calcium and Bone Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism Michael A. Levine Bone Physiology Salvatore Minisola and Lorraine A. Fitzpatrick Pediatric Bone Disease Linda Anne DiMeglio Part V. Gonadal Development Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis Sally Radovick, Helen H. Kim, Diane E. J. Stafford, Andrew Wolfe, and Marjorie Zakaria Sexual Differentiation Tamara S. Hannon and John S. Fuqua Prenatal Androgens and Sexual Differentiation of Behavior Sheri A. Berenbaum Normal and Precocious Puberty Joan DiMartino-Nardi Delayed Puberty Steven G. Waguespack and Ora Hirsch Pescovitz Part VI. Adrenal Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis Sophia P. Tsakiri, George P. Chrousos, and Andrew N. Margioris Molecular Genetics of Adrenal Disease Perrin C. White Index