The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.

Autorentext
Dr. Hassan Marzban (Editor) is a human anatomist and cerebellar developmental biologist, at Department of Human Anatomy and Cell Sciences, the College of Medicine, Faculty of Health Sciences, University of Manitoba. Dr. Marzban is a pioneer in the field and his research is focused to understand the cellular and molecular mechanisms of the developing cerebellum and neurodevelopmental disorders and disabilities.

Inhalt

Chapter1. The development of the cerebellum: from the beginnings.- Part I: Responsibilities and liabilities.- Chapter2. The embryology and anatomy of the cerebellum.- Chapter 3. Cellular and genetic programs underlying cerebellum development.- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. Chapter5. Cerebellar developmental disorders and cerebellar nuclei.- Chapter6. Motor circuit abnormalities during cerebellar development.- Chapter7. Developmental disorders of the cerebellum and neurotrophic factors.- Chapter8. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development.- Chapter9. The ubiquitin proteasome system and cerebellar developmental disease.- Chapter10. Epigenetics and Cerebellar Neurodevelopmental Disorders.- Chapter11. Hormonal regulation of cerebellar development and its disorders.- Chapter12. Infections of the Cerebellum.- Chapter13. Neuroimmune mechanisms of cerebellar development and its developmental disorders.- Chapter14. Teratogenic influences on cerebellar development.- Chapter15. Primary pediatric brain tumors of the posterior fossa.- Chapter16. Primary pediatric brain tumors of the posterior fossa.- Chapter17. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa.- Chapter18. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder.- Chapter19. Congenital cerebellar disease.- Chapter20. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders.- Chapter21. Epidemiologyof cerebellar disorders.- Chapter22. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum.