Dengue and Zika: Control and Antiviral Treatment Strategies

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa.

For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research.

A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the "salt in the soup" of this book.

Inhalt

1. Introduction to the meeting by co-Chairs

2. Dengue - a current status (Eva Harris)

3. Molecular Biology of Flaviviruses (Mariano Garcia Blanco)

4. Development of novel antivirals against flavivirals (Pei-Yong Shi)

5. Therapeutic antibodies and vaccines (Aravinda de Silva)

6. The flaviviral enzymes (Subhash Vasudeavan)

7. The druggability of flaviviral NS3 protease (Rolf Hilgenfeld)

   8. Dengue protease inhibitors (Christph Nitsche)

8. The multiple targets of flaviviral NS5 (Lim Siew Pheng)

9. The flaviviral NS proteins and their interactions (Julien Lescar)

10. The nucleo-cytoplasmic transport of C, NS4B and NS5 (David Jans)

11. Flaviviral glycobiology (Nicole Zitssen)

    13. Development of iminosugar drugs against dengue (Aruna Sampath)

12. T-cells in dengue (Laura Rivino)

13. Evolution of dengue and Zika (Vijay Dhanasekaran)

14. Vector control (Scott O'Neil)

15. Host targets of dengue (Mariano Garcia Blanco)

    18. Animal models of dengue (Katja Fink)

16. Genomic strategies for studies on flaviviruses (Sina Bavari)

17. Many faces of NS1 (Paul Young)