This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.

Autorentext

Alberto A. Rasia-Filho, MD, PhD, is Professor, Department of Basic Sciences/Physiology and Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, and Graduate Program in Neuroscience, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Maria Elisa Calcagnotto, MD, PhD, is Professor, Department of Biochemistry, Graduate Program in Biochemistry, Graduate Program in Neuroscience, and Graduate Program in Psychiatry and Behavioral Science, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Oliver von Bohlen und Halbach, PhD, is Professor, Institut für Anatomie und Zellbiologie, Universitätsmedizin Greifswald, Greifswald, Germany