Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. - Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions - Integrates advances in green chemistry research into industrial applications and process development - Focuses on designing techniques in organic synthesis directed toward mild reaction conditions - Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds

Autorentext

Dr. Davor Margetic is senior research scientist and acting head of the division of organic chemistry and biochemistry at Ruder BoSkovic research Institute in Zagreb, Croatia. He is the head of the laboratory for physical organic chemistry and Professor of physical organic chemistry at Rijeka University.He graduated with a degree in chemical engineering at Zagreb University and continued in the field of organic syntheses with Ms.Sc. and Ph.D. studies in the field of theoretical and physical organic chemistry (Zagreb). The completion of his Ph.D. was followed by a postdoctoral research studies at the Centre for Molecular Architecture, Central Queensland University, Australia. There he worked with Professors Ronald Warrener and Doug Butler for 9 years (synthetic organic and computational chemistry). In 2002, he returned to Croatia to take up a position at RBI, and in 2009 he was promoted to senior research scientist (an equivalent of full professor at the university). Research interests of Dr. Margetic include the synthesis and investigation of theoretically interesting molecules, the study of reaction mechanisms, computational organic chemistry, and the development of environmentally-friendly organic reactions using novel techniques (extreme high pressures, microwave irradiation, and mechanochemistry). During his scientific career, Dr. Margetic has published 90 research papers, 42 electronic conference papers, and 9 book chapters. He has authored one book: "Microwave Assisted Cycloaddition Reactions" with Nova Science Publishers, New York (2011); and edited two books: Croatica Chemica ActA Special issue dedicated to the 70th birthday of Professor Z. B. Maksic (2009), and Special issue dedicated to 70th birthday of Professor M. Eckert-Maksic (2014).

Klappentext

Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency.

The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area.

• Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions
• Integrates advances in green chemistry research into industrial applications and process development
• Focuses on designing techniques in organic synthesis directed toward mild reaction conditions

• Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds

  Inhalt

  Chapter 1. Practical Considerations in Mechanochemical Organic Synthesis

  Chapter 2. Carbon-Carbon Bond- Forming Reactions

  Chapter 3. Carbon-Nitrogen Bond-Formation Reactions

  Chapter 4. Carbon-Oxygen and Other Bond-Formation Reactions

  Chapter 5. Cycloaddition Reactions

  Chapter 6. Oxidations and Reductions

  Chapter 7. Applications of Ball Milling in Nanocarbon Material Synthesis

  Chapter 8. Applications of Ball Milling in Supramolecular Chemistry

  Chapter 9. Experiments for Introduction of Mechanochemistry in the Undergraduate Curriculum