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Dynemicin A, Uncialamycin and Analogues

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  • 144 Seiten
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Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in ... Weiterlesen
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Beschreibung

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments.  However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved.  This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.


  • Presents two natural ènediynes with similar structures whose total syntheses have been accomplished
  • Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity
  • Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted
  • Features studies of the biological activities and data to bring out the structural elements of these essential compounds


Daniel Best is a postdoctoral researcher at the University of Rennes 1 in France. He is currently developing the synthesis of uncialamycin analogues.

Produktinformationen

Titel: Dynemicin A, Uncialamycin and Analogues
Autor:
EAN: 9780081010860
Digitaler Kopierschutz: Adobe-DRM
Format: E-Book (pdf)
Hersteller: Elsevier Science
Genre: Medizin
Anzahl Seiten: 144
Veröffentlichung: 17.06.2016
Dateigrösse: 9.7 MB
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