Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given micro-organism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses.
Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents.

Klappentext

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

Inhalt

Introduction: Cytokine Biology Relevant to Infectious Diseases Charles A. Dinarello I. Cytokines in Infectious Diseases Leptin: Its Role in Immunomodulation and Susceptibility to Infection Graham Lord Cytokine Gene Polymorphism and Host Susceptibility to Infection Frank Stüber II. Cytokines in Gram-Negative Infections Proinflammatory and Anti-Inflammatory Cytokines as Mediators of Gram-Negative Sepsis Jean-Marc Cavaillon Host Response to Pathogenic Bacteria at Mucosal Sites Laurence Arbibe and Philippe Sansonetti Macrophage Migration Inhibitory Factor as a Cytokine of Innate Immunity Thierry Calandra III. Cytokines in Gram-Positive Infections Cytokine Patterns in Severe Invasive Group A Streptococcal Infections Anna Norrby-Teglund and Malak Kotb Superantigens and Bacterial DNA as Cytokine Inducers in Gram-PositiveSepsis Klaus Heeg Cytokines and Chemokines in Listeriosis Michael S. Rolph and Stefan H. E. Kaufmann IV. Cytokines in Mycobacterial Infections Regulation of Cytokines and Chemokines Responses in Human Mycobacterium tuberculosis Infection Zahra Toossi and Jerrold J. Ellner Cytokines and Chemokines in Protective and Inflammatory Responses to Infection with Nontuberculous Mycobacteria Stefan Ehlers Human Interleukin-12-Interferon-g Axis in Protective Immunity to Mycobacteria Claire Fieschi, Stéphanie Dupuis, Capucine Picard, and Jean-Laurent Casanova Role of Th1 Cytokines in Host Defenses Against Mycobacterium leprae Elizabeth Pereira Sampaio, Milton Ozorio Moraes, M. Cristina Vidal Pessolani, and Euzenir Nunes Sarno V. Cytokines in Other Bacterial Infections Possible Role of Molecular Mimicry in Lyme Arthritis Abbie L. Meyer and Brigitte T. Huber Cytokine Responses in Patients withPneumonia Peter Kragsbjerg and Hans Holmberg VI. Cytokines in Fungal Infections Cytokines and the Host Defense Against Aspergillus fumigatus Emmanuel Roilides, Joanna Filioti, and Cristina Gil-Lamaignere Cytokines of Innate and Adaptive Immunity to Candida albicans Luigina Romani VII. Cytokines in Parasitic Infections Th1 and Th2 Cytokines in Leishmaniasis Fabienne Tacchini-Cottier, Geneviève Milon, and Jacques A. Louis Cytokines in the Regulation of Innate and Adaptive Immunity to Toxoplasma gondii Ulrike Wille and Christopher A. Hunter VIII. Cytokines in Viral Infections Viroceptors: Virus-Encoded Receptors for Cytokines and Chemokines Grant McFadden Chemokines and Chemokine Receptors in HIV Infection Paolo Lusso Cytokines in Viral Hepatitis Mala K. Maini and Antonio Bertoletti IX. Cytokines as Therapeutic Agents in Infectious Diseases Interferon-g in the Treatment of Infectious Diseases Steven M. Holland and John I. Gallin Interleukin-2 for the Treatment of HIV Infection Guido Poli, Claudio Fortis, Adriano Lazzarin, and Giuseppe Tambussi Clinical Applications of G-CSF and GM-CSF in the Treatment of Infectious Diseases Kai Hübel, David C. Dale, Richard K. Root, and W. Conrad Liles X. Anticytokine-Based Therapy in Treatment of Infectious Diseases Anticytokine Therapies in Patients with Severe Sepsis and Septic Shock Pierre-Yves Bochud, Michel P. Glauser, and Thierry Calandra Intravenous Immunoglobulin Adjunctive Therapy in Patients with Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis Anna Norrby-Teglund, Donald E. Low, and Malak Kotb Index