Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies

Cytogenetics, fluorescence in situ hybridization (FISH) and molecular tests, especially polymerase chain reaction (PCR), play an important role in the management of patients with hematologic malignancies by helping to establish the diagnosis, as well as predict prognosis, response to treatment and disease progression. Chromosomal and molecular abnormalities provide the most reliable criteria for classification of hematopoietic tumors and often comprise the basis for targeted therapy.
Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies, provides a review of chromosomal and molecular changes in hematologic malignancies and correlates the karyotypic and genetic abnormalities with morphology, immunophenotype and clinical data. With over 180 figures and diagnostic algorithms, this text is essential reading for all pathologists, hematopathologists, hematologic oncologists, cytogenetists, cytogenetic technologists and cell biologists.

Autorentext

Director of Hematopathology/Oncology Services (New York), Genzyme Genetics, USA

Inhalt

Chapter I. Introduction. Chapter II. Applications of cytogenetics, FISH and PCR in the diagnosis, prognosis and disease monitoring. Chapter III. Hematological malignancies: Correlation between morphology, phenotype and chromosomal/genetic markers.