Cyclitols and Phosphoinositides

Cyclitols and Phosphoinositides covers the proceedings of the 1977 Conference on Cyclitols and Phosphoinositides, held at the Kellogg Center for Continuing Education, Michigan State University, East Lansing, Michigan.
This book is organized into eight parts encompassing 43 chapters. The first parts describe the chemistry of cyclitols, inositol phosphates, and phosphoinositides. The subsequent parts explore the ubiquitous myoinositol and its phospholipids in animals, plants, yeast, bacteria, and molds; in various body parts, such as iris, brain, nerves, pineal, testis, lymphocytes, pancreas, parotid, retina, synapses, lysosomes; and the test tube. The last parts consider the mechanism of inositol biosynthesis and the meaning of increased phosphatidylinositol turnover in response to extracellular stimuli.
This book will prove useful to research workers in the fields of organic chemistry, biochemistry, genetics, physiology, microbiology, pharmacology, botany, and nutrition.

Inhalt

List of Contributors

Preface

Part I: Chemistry of the Cyclitols

Artificial Lipids Containing Cyclopentanoid Backbones

Intramolecular Aldol Condensations of Delta-Dicarbonyl Sugars-A Novel

Approach to the Syntheses of Cycloses

The Isolation and Identification of Inositol Phosphate Intermediates by Ion Exchange Chromatography

Chemistry and Physiology of myo-Inositol Esters of I ndole-3-Acetic Acid

Part II: Inositol Phosphates and Phosphoinositides

A Novel Metabolic Cycle Involving /wyo-Inositol Phosphates during Formation and Germination of Seeds

Phosphoinositol Kinase from Plant and Avian Sources

Phosphoinositides of Fungi and Plants

Part III: Phosphoinositides I

The Acetylcholine Phospholipid Effect: What Has It Told Us? What Is It Trying to Tell Us?

Studies on the Role of Triphosphoinositide in Cholinergic Muscarinic and a-Adrenergic Receptors Function of Iris Smooth Muscle

Phosphatidylinositol, Triphosphoinositide, and Synaptic Transmission

Interaction of Aminocyclitol Antibiotics with Polyphosphoinositides in Mammalian Tissues and Artificial Membranes

Nature of the Receptors which Mediate Enhanced Phosphatidylinositol Turnover in Rat Pineal Gland

Modification of Phosphatidylinositol Metabolism by Propranolol and Local Anesthetics

Phosphatidylinositol Metabolism in Rat Brain Preparations

Selectivity in Pathways of Cytidine Diphosphate Diacylglycerol Formation

Effects of Cyclic Nucleotides and Related Agents on Renal Polyphosphoinositicje Metabolism

Part IV: Biosynthesis of Inositol

Some Enzymes of Inositol Metabolism, Their Purification and Their Mechanism of Action

Aspects of myo-Inositol Metabolism and Biosynthesis in Higher Plants

Intermediates in the wyo-Inositol 1-Phosphate Synthase Reaction

Studies on Enzymes of Inositol Metabolism

Further Characterization of the myo-Inositol 1-Phosphate Synthase from Neurospora crassa

Inositol-1-Phosphate Synthase Mutants of the Yeast, Saccharomyces cerevisiae

The Distribution of Radioactive myo-Inositol in the Reproductive Tract of the Male Rat. The Blood-Testis Barrier to myo-Inositol

Part V: Phosphoinositides II

The Influence of Intracellular Ca2+ on the Metabolism of Inositol Phospholipids in Lymphocytes and Erythrocytes

Phosphatidylinositol Hydrolysis and Insulin Secretion from the Rat Pancreatic Islet

The Mechanism of Stimulated Phosphatidylinositol Breakdown

Colchicine Enhances myo-Inositol Stimulation of Secretion by Rat Pancreatic Tissue in Vitro

Hormonal Effects on myo-Inositol Metabolism in the Dog

Phosphatidylinositol Kinase and Diphosphoinositide Kinase in the Rat Parotid Gland

Studies of Phosphatidylinositol Phosphodiesterase

Part VI: Function I

Biosynthesis of Aminocyclitols and Guanidinocyclitols

The Role of Inositol Glucosides in the Synthesis of 01, 3-Glucans

Abnormal Lipid Metabolism due to myo-Inositol Deficiency in Rats and Yeast

Requirement for Dietary myo-Inositol in the Lactating Rat

Part VII: Function II

Active Transport of Cyclitols in Bacteria

Cyclohexitol Transport in the Central Nervous System

Lithium and Brain myo-Inositol Metabolism

Part VIII: Phosphoinositides III

Studies on the Metabolic Heterogeneity of Different Molecular Species of Phosphatidylinositols

Phosphoinositide Metabolism in Peripheral Axons

The Arachidonoyl Groups of Phosphatidylinositols in Brain Synaptosomes

Metabolism of Phosphatidylinositol in the Retina

Tissue Culture Studies on the Metabolism of myo-Inositol

Acidic PhosphoUpids and Lysosomal Bis (Monoacylglyceryl) Phosphate Synthesis: The Role of Phosphatidylinositol and Lysophosphatidylglycerol

Concluding Remarks

Index