This book constitutes the refereed proceedings of the 22nd International Conference on Cryptology and Network Security, CANS 2023, which was held in October/November 2023 in Augusta, GA, USA. The 25 papers presented were thoroughly revised and selected from the 54 submissions. They are organized in the following topical sections: Schemes I; Basic Primitives; Security; MPC with Cards; Blockchain; MPC and Secret Sharing; Schemes II.