COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. The discovery of COX-2, the evolution of drug development in this field and the implications of these developments in patient therapy are topics of this volume. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

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List of contributors. Preface. R. M. Botting and J. H. Botting: The discovery of COX-2. Lawrence J. Marnett and Amit S. Kalgutkar: Structural diversity of selective COX-2 inhibitors. Guenter Trummlitz, Joanne van Ryn and Timothy D. Warner: The molecular and biological basis for COX-2 selectivity. Kim Rainsford: Pharmacology/ toxicology of COX-2 agents. Frank Degner: Efficacy and gastrointestinal safety of selective COX-2 inhibitors. Joanne van Ryn and Michel Pairet: Role of COX-2 in ulcers and ulcer healing. Rahul Nayak and Brendan F. McAdam: COX-2 and the cardiovascular system. Dirk O. Stichtenoth: Effects on the kidney: Role of COX-2 inhibitors. Koichi Hashimoto and R. Stokes Peebles Jr.: Effects on the lungs: Role of COX-2 inhibitors. Phillip R. Bennett and Aarthi R. Mohan: Reproduction: Role of COX-2 and its inhibition. Kirsi Saukkonen, Christianne J. Buskens, Anna Sivula, Bastiaan P. van Rees, Tiina-Liisa Erkinheimo, Johanna Rintahaka, Leena Pohjola, J. Jan B. van Lanschot, G. Johan A. Offerhaus, Caj Haglund and Ari Ristimäki: COX-2 in cancer. Index