This book constitutes the thoroughly refereed conference proceedings of the 10th International Conference on Computational Methods in Systems Biology, CMSB 2012, held in London, UK, during October 3-5, 2012. The 17 revised full papers and 8 flash posters presented together with the summaries of 3 invited papers were carefully reviewed and selected from 62 submissions. The papers cover the analysis of biological systems, networks, and data ranging from intercellular to multiscale. Topics included high-performance computing, and for the first time papers on synthetic biology.

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Differential and Integral Views of Gene-Phenotype Relations.- Resolving the Three-Dimensional Histology of the Heart.- Bimodal Protein Distributions in Heterogeneous Oscillating Systems.- Expressive Statistical Model Checking of Genetic Networks with Delayed Stochastic Dynamics.- Detection of Multi-clustered Genes and Community Structure for the Plant Pathogenic Fungus.- Analysis of Modular Organization of Interaction Networks Based on Asymptotic Dynamics.- Concretizing the Process Hitting into Biological Regulatory Networks.- Investigating Co-infection Dynamics through Evolution of Bio-PEPA Model Parameters: A Combined Process Algebra and Evolutionary Computing Approach.- Population Dynamics P Systems on CUDA.- Efficient Handling of Large Signaling-Regulatory Networks by Focusing on Their Core Control.- Simulating Insulin Infusion Pump Risks by In-Silico Modeling of the Insulin-Glucose Regulatory System.- Revisiting the Training of Logic Models of Protein Signaling Networks with a Formal Approach Based on Answer Set Programming.