• Biological examples motivate concepts and techniques used in computational cell biology through a progression of increasingly more complex cellular functions modelled with complex mathematical computational techniques. - A focused introduction that is aimed at advanced undergraduate and graduate biologists and who are mathematically minded and math students who wish to learn about modeling in cell biology.

Klappentext

This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.

Inhalt

Preface.-Introductory Course.-Dynamic Phenomena in Cells.-Voltage Gated Ionic Currents.-Transporters and Pumps.-Fast and Slow time Scales.-Whole Cell Models.-Intercellular Communication.-Advanced Material.-Spatial Modeling.-Modeling Intracellular Calcium Waves and Sparks.-Biochemical Oscillations.-Cell Cycle Controls.- Modeling the Stochastic Gating of Ion Channels.-Molecular Motors: Theory.-Molecular Motors: Examples.-Numerical Algorithms.-References.-Index.