An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. The volume closes with an outlook on future perspectives.

Inhalt

Anti-HIV agents to be used in drug combination regimens.- A perspective of the history of HAART.- The basic principles for combination therapy.- Comparison of the efficacy of HAART: single, dual or triple-class antiretroviral therapy.- Pharmacokinetics and pharmacodynamics of HAART.- Primary HIV infection: from diagnosis to treatment.- Salvage therapy.- Structured therapy interruptions (STIs): lessons from a therapeutic strategy.- Immune reconstitution in HIV infection.- Highly active antiretroviral treatment (HAART) of pediatric HIV-1 infection.- Causes of HIV treatment failure.- Economic implication of HIV-1 resistance testing in overall clinical care.- Guidelines for antiretroviral therapy.- Visions for the future of antiretroviral therapy.