The rapid growth over the past decade in the number of options available to manage colorectal cancer patients has created a need to unify this scattered knowledge so that practitioners in one area of treatment can understand the expertise of colleagues working in other areas. In Colorectal Cancer: Multimodality Management, Leonard Saltz, MD, has brought together a team of leading clinical, surgical, and radiation oncologists, as well as those specialists involved in pain management, diagnostic imaging, and complementary medicine, to create a unified vision of the many new possibilities for managing colorectal cancer. Here the practicing clinician will find cutting-edge reviews on advances in diagnostic and therapeutic radiology and the surgical aspects of treating colorectal cancer, the major therapeutic agents, the currently available drugs for first- and second-line management of metastatic colorectal cancer, chemotherapy for adjuvant management, and local regional therapies. Additional reviews explain the molecular genetic events that occur in colorectal cancer, the new understanding of dietary and environmental factors, , possible strategies for prevention, pain control, and complementary and alternative medicine approaches, and sexuality and fertility in the colorectal cancer patient.
Evidenced-based, multidisciplinary, and cutting-edge, Colorectal Cancer: Multimodality Management provides busy oncologists, gastroenterologists, surgeons, and radiation therapists an authoritative review of the best currently available approaches to the prevention, diagnosis, and treatment of colorectal cancer.

Klappentext

The rapid growth in the number of options available for the management of colorectal cancer presents the clinician with new opportunities and new complexities. An explosion of understanding in the basic science that underlies both the disease and its potential therapies has translated into remarkable technological advances that can now be applied. So many specialties and subspecialties have now been brought to bear that it is appropriate to attempt to bring the expertise from these areas together in one volume, so that practitioners in one aspect of colorectal cancer management can maintain knowledge and expertise regarding the capabilities of other colleagues working in this disease. Colo rectal Cancer: Multimodality Management provides a concise, focused, and current review of the methodological and technological advances that have recently occurred in the management of colorectal cancer. The book has been divided into six basic parts. The first part, dealing with epidemiology and prevention, focuses on the molecular genetic events that occur in the development of colorectal cancer, as well as on our understanding of dietary and environmental factors, and possible strategies for prevention. Part II focuses on both diagnos­ tic and therapeutic radiology in the management of colorectal cancer, dealing with innumer­ able advances in imaging, and with the progress in the science and art of radiation therapy. The third section deals with the surgical aspects of management of colorectal cancer, starting with surgical pathology.

Inhalt

Part I. Epidemiology/Prevention Biology and Molecular Genetics of Colorectal Cancer Scott K. Kuwada, Deborah W. Neklason, and Randall W. Burt Epidemiological Trends in Colorectal Cancer Susan M. Talbot and Alfred I. Neugut Dietary and Lifestyle Influences on Colorectal Carcinogenesis Charles S. Fuchs Screening and Surveillance Arnold J. Markowitz Chemoprevention of Colorectal Cancer Monica M. Bertagnolli Management of Hereditary Colon Cancer Syndromes Miguel A. Rodriguez-Bigas and Nicholas J. Petrelli Part II. Diagnostic and Therapeutic Radiology Overview of CT, MRI, and Ultrasound in the Imaging and Staging of Colorectal Cancer David J. Vining Virtual Colonoscopy for Colorectal Cancer Screening and Surveillance David T. Rubin and Abraham H. Dachman Preoperative Staging of Rectal Cancer: Endorectal Ultrasound and Endorectal MRI Spiros Hiotis, Sharon Weber, and W. Douglas Wong Nuclear Medicine in the Diagnosis and Management of Colorectal Cancer Stanley J. Goldsmith and Lale Kostakoglu Radiation Therapy of Resectable Rectal Cancer Nora A. Janjan, Matthew Ballo, Christopher Crane, and Marc Delclos Management of Locally Unresectable Rectal Cancer Bruce D. Minsky Radiation Therapy for Hepatic Metastases John M. Robertson Part III. Surgery of Colorectal Cancer Surgical Pathology of Colorectal Cancer Carolyn C. Compton Surgery of Colon Cancer Alfred T. Culliford IV and Philip B. Paty Laparoscopy in Colorectal Cancer Management Heidi Nelson and Bernardo Tisminezky Management of Cancer in a Polyp David A. Rothenberger and Julio Garcia-Aguilar Surgery of Rectal Cancer Aaron R. Sasson and Elin R. Sigurdson Conservative Management of Early-Stage Rectal Cancer Mitchell C. Posner and Glenn D. Steele, Jr. Surgical Management of Hepatic Colorectal Metastases William R. Jarnagin and Yuman Fong Resection of Colorectal Metastases to the Lung Robert J. Downey Surgical Management of Peritoneal Surface Spread of Colorectal Cancer Paul H. Sugarbaker Cryosurgical Ablation for the Management of Unresectable Hepatic Colorectal Metastases Gregory D. Kennedy, Fred T. Lee, Jr., David Mahvi, and John E. Niederhuber Radiofrequency Ablation of Colorectal Metastases to the Liver Douglas L. Fraker Part IV. Medical Oncology 5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer Jean L. Grem Clinical Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacology Robert B. Diasio Oral Fluoropyrimidines in Colorectal Cancer John L. Marshall Irinotecan in the Treatment of Colorectal Cancer Leonard B. Saltz Oxaliplatin in the Treatment of Colorectal Cancer Stacy D. Jacobson, Steven R. Alberts, and Richard M. Goldberg TS Inhibitors and Antifolates Hugo E. R. Ford and David Cunningham Adjuvant Therapy for Colon Cancer Kyle Holen and Leonard B. Saltz Hepatic Artery Infusion M. Margaret Kemeny and Nancy E. Kemeny Intraportal and Intraperitoneal Chemotherapy for Colon Cancer Werner Scheithauer Molecular Markers of Chemotherapy Resistance in Colorectal Cancer Peter V. Danenberg Part V. Supportive Management Cancer Pain Syndromes in Colorectal and Anal Cancers Nathan I. Cherny Pain Management in Colorectal and Anal Cancers Nathan I. Cherny Sexuality and Fertility in Patients with Colorectal Cancer Megan P. Fleming Complementary and Alternative Medicine Approaches in Colorectal Cancer Andrew J. Vi