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Epidemiology of Sepsis.- The Systemic Inflammatory Response Syndrome (SIRS).- The "At Risk" Patient Population.- Outcome and Prognostic Factors in Bacteremic Sepsis.- ARDS and Sepsis: Resemblances and Differences.- Monitoring the Treatment of Sepsis.- Microbiological Requirements for Studies of Sepsis.- Measurement of Inflammatory Mediators in Clinical Sepsis.- Whole Body and Organ Measures of 02 Availability.- Multiple Organ Dysfunction Syndrome (MODS).- Monitoring Illness Severity.- What Determines Prognosis in Sepsis?.- SAPS II and MPM II Models for Early Severe Sepsis.- Clinical Management of Sepsis.- Fluid Therapy in Septic Shock.- Role of RBC Transfusion Therapy in Sepsis.- Vasoactive Drug Therapy in Sepsis.- Evidence-Based Analysis of Nutrition Support in Sepsis.- Investigational Therapy of Sepsis.- Anti-Endotoxin Therapy.- Critical Reappraisal of Steroids and Other Anti-Inflammatory Agents.- Investigational Therapy of Sepsis: Anti-TNF, IL-1ra, Anti-PAF and G-CSF.- Sepsis and Acute Lung Injury.- Increasing Oxygen Delivery in Sepsis.- Designing the Optimum Clinical Trial for the Treatment of Sepsis.- Critical Evaluation of the Design and Conduct of Previous Clinical Trials in Sepsis.- Evaluation of the Adequacy of Source Control.- Statistical Considerations for the Design of the Optimal Clinical Trial.- The Monitoring and Reporting of Clinical Trials.- Economic Evaluation in the Critical Care Literature.- Ethical Issues in Clinical Trials.