Proceedings of the NATO Advanced Research Workshop on Chromosome Segregation and Aneuploidy, held at Aghia Pelagia, Greece, October 10-15, 1992

Inhalt

Chromosome Segregation and Aneuploidy.- Structure of the Mammalian Centromere.- Properties of CENP-B and Its Target Sequence in Satellite DNA.- The Minor Satellite of Mouse and the Centromere.- Centromere Organization in Man and Mouse.- New Tools for the Study of Chromosome Segregation and Aneuploidy at the Molecular Level.- Premature Centromere Division and Other Centromeric Misbehaviour.- Genetic Approaches for Identifying Kinetochore Components in Saccharomyces Cerevisiae.- Cell Cycle Regulation of Centromere Function in Saccharomyces Cerevisiae.- Sensing DNA Damage: a Role for Chromosome Communication in Aneuploidy Induction.- The Acquisition and Association of TG1-3 Single-Strand Tails During Replication of Saccharomyces Telomeres.- Transposition as a Mechanism for Maintaining Telomere Length in Drosophila.- Molecular Features of Heterochromatin Condensation.- RCC1-Ran-RanGAP Signal for Initiation of Mitosis.- Implications of Cell Cycle Disturbances for Meiotic Aneuploidy: Studies on a Mouse Model System.- Morphogenesis of the Mitotic and Meiotic Spindle: Conclusions Obtained from One System Are Not Necessarily Applicable to the Other.- A Genetic Analysis of Microtubule Assembly and Function in Yeast.- The Events and Regulation of Anaphase Onset.- Microtubule Converging Centers - Implications for Microtubule Dynamics in Higher Plants.- Development of Kinetochores During Early Mitosis in HeLa Cells and the Stability of a Trilaminar Kinetochore Structure.- Are Topoisomerases Required for Mammalian Chromosome Segregation?.- Possible Targets for the Aneugenic Activity of Alkylating Agents.- The Relationship Between Chemically-Induced Meiotic Delay and Aneuploidy in Mouse Oocytes and Zygotes.- Correlation Between Induction of Meiotic Delay and Aneuploidy in Male Mouse Germ Cells.- Analysis of Micronuclei and Microtubule Arrangement to Identify Aneuploidy-Inducing Agents in Cultured Mammalian Cells.- Effects of Antitopoisomerase Drugs on Chromosome Recombination and Segregation in Grasshopper.- Disruption of Centromere Function by 2-Aminopurine.- Induction of Mitotic Aneuploidy in Lower Eukaryotes.- In Vivo Assay for Detection and Evaluation of Aneugens.- Multicolor Fluorescence in situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei.- The Detection, Definition and Regulation of Aneugenic Chemicals.