The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.

This set of books* gives a state-of-the-art account of recent developments in this field in the form of summaries written by highly regarded experts. Volume I is focused on basic principles and progress in chemokine biology, and Volume II deals with issues related to chemokine-related drug development and potential therapeutic applications. These volumes provide both introductory and novel information for a broad readership, including clinicians and biomedical scientists.

*See also K. Neote/G.L. Letts/B. Moser, Chemokine Biology - Basic Research and Clinical Application. Volume II: Pathophysiology of Chemokines. 2006, Birkhäuser, Progress in Inflammation Research, ISBN 3-7643-7195-1.

Zusammenfassung

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV.
Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.

Inhalt
Cellular targets in innate and adaptive immunity.- Traffic of T lymphocytes.- Lymphocyte homing to peripheral epithelial tissues.- Chemokine biology of NK cells and ?? T cells.- Dendritic cell traffic control by chemokines.- Chemokine receptor-mediated signal transduction.- Chemokines in leukocyte transendothelial migration.- Natural chemokine antagonism and synergism.- Effector cell traffic-unrelated functions.- Crosstalk between chemokine, opioid, and vanilloid receptors.- Antimicrobial and related activities of chemokines.- Virus-encoded chemokine modulators as novel anti-inflammatory reagents.- Chemokine receptors in tissue cells and angiogenesis.