This book presents paradigms for the current status of therapeutic approaches using mammalian cells after ex vivo processing. The improvement of basic knowledge in cell physiology, cellular pharmacology, and in molecular medicine has paved the way for cellular therapy in several disciplines. Consequently, there is increasing interest of the specialists to exchange knowledge and methodologies with their colleagues from other areas to speed up the development of a meaningful therapy. This book not only summarizes current knowledge and technologies in this field but additionally delivers views and assessments of the chances and limitations, strategies and needs for cellular therapy of the future. Thus, the interested reader will find both, basic information and advanced skills presented by outstanding scientists in the field.

Klappentext

The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re­ sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol­ ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat­ ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat­ ment of tumors resistant to chemotherapy, radiation therapy, or hor­ mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.

Inhalt

1 Somatic Gene Therapy in Cancer.- 2 Placental Blood: New Options in Hematopoietic Stem Cell Transplantation.- 3 Recent Developments in the Ex Vivo Manipulation of Hematopoietic Cells from Bone Marrow and Blood.- 4 Monocyte-Derived Cells in Adoptive Immunotherapy of Cancer: Facts and Perspectives.- 5 The Immunological Basis for the Development of Tumor Cell- and Peptide-Based Vaccines for Treatment of Patients with Renal Cell Carcinoma.- 6 Transplantation of Isolated Islets of Langerhans as Treatment of Diabetes Mellitus.- 7 Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis.- 8 Neuronal Modulation of the Immune Response in Nervous Tissue: Implications for Neurodegenerative and Autoimmune Diseases.- 9 Transplantation of Dopamine-Synthesizing Cells in Parkinson's Disease: Experimental Data and Clinical Application.- 10 Repairing CNS Demyelination by Glial Cell Transplantation.- 11 Monitoring of Suicide Gene Therapy with Positron Emission Tomography.- Previous Volumes Published in this Series.