This book highlights cutting-edge studies in the development of cell-inspired biomaterials and synthetic materials that manipulate cell functions and provide the next generation with contemporary tools for treating complex human diseases. It explores the convergence of synthetic materials with cell and molecular biology and surveys how functional materials, when patterned with spatial and temporal precision, can be used effectively to maintain cell proliferation and phenotype in vitro, to trigger specific cell functions, and to redirect cell-fate decisions. Human stem cells are a frequently discussed subject in this book. This is an ideal book for students, cell biologists, researchers interested in interdisciplinary research, and biomedical engineers.

This book also: Highlights successfully developed technologies in cell engineering that make possible new therapeutic development for previously untreatable conditions Covers topics including bio-inspired micropatterning, DNA origami technology, synthetic NOS inspired by compartmentalized signaling in cells, and light-induced depolarization of the cell membrane

Illustrates in detail the use of stem cells and synthetic scaffolds to model ethically sensitive embryonic tissues and organs

Autorentext
Dan Ohtan Wang is an Associate Professor at the Institute for Integrated Cell-Material Sciences (iCeMS).
Daniel Packwood is a Senior Lecturer at the Institute for Integrated Cell-Material Sciences (iCeMS) at Kyoto University.

Inhalt
Part A. Fundamental stem cell science for organ engineering  

Chapter 1. Generation of hepatocytes for human ES/iPS cells for regenerative medicine (Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi)

Part B. Fundamental chemistry for cell-inspired materials and imaging

Chapter 2. Construction of multi-step catalytic systems in protein assemblies (Hiroyasu Tabe, Takafumi Ueno)

Chapter 3. Machine learning and Monte Carlo methods for surface-assisted molecular self-assembly (Daniel M. Packwood)  

Chapter 4. DNA nanotechnology to disclose molecular events at the nanoscale and mesoscale levels (Masayuki Endo)

Part C. Materials and chemicals for cell control

Chapter 5. Materials designed for biological nitric oxide delivery (Shuhei Furukawa)

Chapter 6. Designing bio-mimicking synthetic transcription factors for therapeutic gene modulation (Ganesh N. Pandian, Hiroshi Sugiyama)

Part D. Physical methods for cell control

Chapter 7. Magnetic nanoparticles and alternating magnetic field for cancer therapy: From cells to clinics (Harutaka Mekaru, Yuko Ichiyanagi, Fuyuhiko Tamanoi)

Chapter 8. Light-control of cell membrane potential and its environment (Yuta Takano)

Chapter 9. Physical concepts towards cell-material integration (Motomu Tanaka)

Part E. Artificial environments for cell control

Chapter 10. Using stem cells and synthetic scaffolds to model ethically sensitive human placental tissue (Georgia Kafer)

  Chapter 11. Nanofiber extracellular matrices in regenerative medicine (Ken-ichiro Kamei)