The molecular approach to disease continues to yield a tremendous amount of new information about those aspects of cellular replication that we use to understand, prevent, diagnose, and cure cancer. In Cell Cycle Inhibitors in Cancer Therapy: Current Strategies, recognized clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell-cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor-suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac.
Up-to-date and richly instructive, Cell Cycle Inhibitors in Cancer Therapy: Current Strategies brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Klappentext

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Inhalt

Cdk Inhibitors: Background and Introduction Giulia De Falco, Catherine Soprano, and Antonio Giordano p27, A Prognostic Indicator Reflecting...? Andrew Koff Cell Cycle Control of Transcription at the G1/S Phase Transition André J. van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. Lian Tumor-Suppressor Genes as Diagnostic Tools Lorenzo Leoncini, Cristiana Bellan, Caterina Cinti, and Antonio Giordano Regulation of Cell Cycle and Apoptosis Lucio Miele CDK Inhibitors as Targets of Chemoprevention Agents Joanna K. Sax and Wafik S. El-Deiry Cell Cycle Regulatory Genes as Targets of Retinoids Kenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano, and Dianne R. Soprano Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases Adrian M. Senderowicz Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer Paul J. van Diest and Rob J. A. M. Michalides Cell Cycle Regulators as Targets of Anticancer Therapy Mikhail V. Blagosklonny Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer Valeria Masciullo, Kenneth J. Soprano, and Antonio Giordano Synthetic Oligopeptides as Cancer Cell Cycle Modulators Anna Severino, Armando Felsani, Antonio Giordano, and Marco G. Paggi Index