The past decade has seen an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic matrix. Cardiac Repolarization: Bridging Basic and Clinical Science comprehensively reviews all the latest developments in cardiac electrophysiology, focusing on both clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions, among them early repolarization and short QT interval, Brugada syndrome, long QT syndrome, and sudden infant death syndrome. Chapters delineate objectives and key points, and include established and evidence-based knowledge, current perspectives, areas of controversy, and recommendations for future investigations.
Comprehensive and clinically oriented, Cardiac Repolarization: Bridging Basic and Clinical Science surveys the major research discoveries that have recently transformed our understanding of cardiac electrophysiology and spells out in full detail their clinical implications for the diagnosis and treatment of patients with malignant electrical instability of the heart.

Klappentext

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Inhalt

Part I. Introduction Chapter 1. Ventricular Repolarization and the Identification of the Sudden Death Candidate: Hype or Hope? Hein J. Wellens and Douglas P. Zipes Chapter 2. Historical Milestones of Electrical Signal Recording and Analysis Thorsten Lewalter and Berndt Luderitz Part II. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization Edited by Charles Antzelevitch Chapter 3. Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization Jeanne M. Nerbonne and Robert S. Kass Chapter 4. Electrophysiology and Pharmacology of Ventricular Repolarization Charles Antzelevitch, Andrew C. Zygmunt, and Robert Dumaine Chapter 5. How Do We Measure Repolarization inside the Heart? Charles Antzelevitch, Andrew C. Zygmunt, Jeffrey Fish, Guillermo Perez, and Fabiana Scornik Chapter 6. Contribution of Electrical Heterogeneity of Repolarization to the ECG Charles Antzelevitch and Vladislav V. Nesterenko Chapter 7. Electrical and Structural Remodeling of the Ventricular Myocardium in Disease Antonis A. Armoundas and Gordon F. Tomaselli Chapter 8. Ischemia-Related Changes in Repolarization André G. Kléber and Michiel J. Janse Chapter 9. The Long QT Syndrome: Molecular and Genetic Aspects Carlo Napolitano and Silvia G. Priori Chapter 10. Ion Channel Disease as a Cause of the Brugada Syndrome: Molecular and Genetic Aspects Connie R. Bezzina and Arthur A. M. Wilde Chapter 11. Cellular and Ionic Mechanisms Underlying Arrhythmogenesis Charles Antzelevitch, Alexander Burashnikov, and Jose Di Diego Part III. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice Edited by Steven C. Hammill, Win K-Kuang Shen, and Ihor Gussak Chapter 12. Evaluation of VentricularRepolarization: The Clinician's Perspective Jan Nemec, Steven C. Hammill, and Win-Kuang Shen Chapter 13. Human Cardiac Repolarization Philip T. Sager Chapter 14. QT interval and Its Drug-Induced Prolongation Wojciech Zareba and Arthur J. Moss Chapter 15. Neuro-Mediated Repolarization Abnormalities Philippe Coumel and Pierre Maison-Blanche Chapter 16. The Electrophysiologic Matrix: Equilibrium and Arnsdorf's Paradox Morton F. Arnsdorf Chapter 17. Antiarrhythmic Drugs and Future Direction Arshad Jahangir, Andre Terzic, and Win-Kuan Shen Part IV. Specific Electrocardiographic Phenomena and Clinical Syndromes of Ventricular Repolarization Edited by Ihor Gussak, Charles Antzelevitch, and Preben Bjerregaard Chapter 18. ECG Phenomena of the Early Ventricular Repolarization: Early Repolarization Syndrome Ihor Gussak, Charles Antzelevitch, and Preben Bjerregaard Chapter 19. The Brugada Syndrome Pedro Brugada, Ramon Brugada, Charles Antzelevitch, Koonlawee Nademanee, Jeffrey Towbin, and Josep Brugada Chapter 20. Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome Anant Khositseth and Michael J. Ackerman Chapter 21. Prolonged Repolarization and Sudden Infant Death Syndrome Peter J. Schwartz Chapter 22. Short QT Interval: ECG Phenomenon and Clinical Syndrome, Ihor Gussak, Charles Antzelevitch Daniel Goodman, and Preben Bjerregaard Chapter 23. T-Wave Alterans: Mechanisms, Relevance, and Clinical Implications Etienne Pruvot and David S. Rosenbaum. Index.