Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

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List of contributors. Preface; M.M. LeWinter, et al. 1. Energy costs of PVA and Emax: constancy and variability; H. Suga, et al. 2. Kinetic property of cardiac myosin in vitro; S. Sugiura, et al. 3. Thin filament regulation and cardiac energetics; R.J. Solaro. 4. Explaining load-dependent ventricular performance and energetics based on a model of E-C coupling; D. Burkhoff, et al. 5. Cardiac contractions. PVA and energetic considerations determined from a cardiac muscle crossbridge model; T.W. Taylor, et al. 6. Normalization of Emax and PVA; M. Sugawara, et al. 7. Observations on the relation of PVA and MVO2 in closed chest dogs; G.L. Freeman, S.D. Prabhu. 8. Regional myocardial contraction coupled with energetics; Y. Goto, et al. 9. Energetics during ventricular fibrillation; H. Kusuoka, E. Marbab. 10. Influence of preload on non-mechanical VO2 assessed with 2,3-butanedione monoxime; M.M. LeWinter, et al. 11. Emax and myocardial microcirculation; F. Kajiya, et al. 12. Efficiency of ventricular-arterial coupling and baroreflex regulation of blood pressure; K. Sunagawa, et al. 13. Ventriculo-arterial load matching of failing hearts; H. Asanoi, et al. 14. Calcium signalling and pharmacology of cardiotonic agents; M. Endoh. 15. Effect of inotropic agents on mechanoenergetics in human diseased heart; M. Takeuchi, et al. 16. Effects of various inotropic agents on the relation between ventriculoarterial coupling and myocardial energetics in patients with idiopathic dilated cardiomyopathy; M. Yokota, et al. Index.