Wallace O. Fenn (1893-1971) The proceedings of the satellite sym­ encompass the whole of physiology. His con­ posium of the XXV International Congress tributions over 50 years covered four main of Physiology on "C0 and Metabolic eras in the development of physiology: 2 Regulations" are dedicated to Wallace muscle, electrolyte, respiratory, and hyper­ Osgood Fenn. Dr. Fenn had agreed to be baric study. honorary conference chairman of this meet­ The study of muscle contraction started ing, but was unable to attend because of the in 1922 when Fenn became the first American to work in A. V. Hill's laboratory. Fenn illness from which he died two months later concluded this work by saying, " ... There on September 20, 1971. Wallace O. Fenn was born of an old is a fairly good quantitative relation between New England family in Lanesboro, Massa­ the heat production of muscles and the work chusetts on August 27, 1893. His father was which they perform; and a muscle which does dean of the Divinity School at Harvard ~ork liberates, ipso facto, an extra supply of University. It was at Harvard that Fenn energy which does not appear in an isometric received his A.B. (1914) and his M.S. (1916). contraction." (Fenn [1923]). A. V. Hill referred to this as the "Fenn effect," and so He then started his Ph.D. thesis there under the plant physiologist W. J. V. Osterhout, it has been known ever since.

Inhalt

Preface.- Dr. Fenn's Last Manuscript: An Exchange of Correspondence: Gabriel G. Nahas.- Carbon Dioxide and the Sea: Wallace O. Genn.- I Carbon Dioxide and pH Regulation of Basic Metabolic Processes.- 1. Carbon Dioxide and Metabolic Regulations in Plant Photosynthesis.- 2. The Regulation by Carbon Dioxide of Carbohydrate and Lipid Metabolism in Isolated Perfused Tissue.- 3. Nature of Dynamics of Cellular Carbon Dioxide.- 4. Relationships between Blood and Extravascular Pco2, [H+], and [HCO3?], Lung, Cerebrospinal Fluid, and Brain.- II Carbon Dioxide and pH Regulation of Cellular Functions.- 1. Carbon Dioxide Effects on Nerve Cell Function.- 2. Simultaneous Recordings of pH, Pco2, and Neuronal Activity during Hypercapnic Transients.- 3. Carbon Dioxide Action on Neuronal Membranes.- 4. Carbon Dioxide in Developmental Processes.- 5. Mechanisms of Carbon Dioxide and pH Effects on Metabolism.- 6. Carbon Dioxide Respiratory Regulation and Chronobiology.- III Carbon Dioxide and pH Effect on Oxygen and Carbon Dioxide Transport.- 1. Effect of Acid-Base Status on Oxygen Transport by Whole Blood.- 2. The Influence of pH and Oxygen on the Erythrocyte Content of 2, 3-Diphosphoglycerate.- 3. Carbon Dioxide Transport.- 4. Carbon Dioxide and the Utilization of Oxygen.- 5. Pco2, pH, and Body Temperature.- 6. Carbon Dioxide and Temperature Regulation of Homeothermic Mammals.- IV Carbon Dioxide and Regulation of Organ Function.- 1. Bone Carbon Dioxide Stores and Acid-Base Regulation.- 2. Continuous Control of Intravascular Pco2 and Reflexogenic Effects of Carbon Dioxide on the Pulmo-Cardio-Vascular System in sita.- 3. The Effects of Carbon Dioxide and pH on the Regulation of the Pulmonary Circulation.- 4. Carbon Dioxide and the Kidney.- 5. Scanning Electron Microscopy of the Urinary Pole of the Distal Tubule Cells in the Rat Subjected to Respiratory Acidosis and to Metabolic Alkalosis.- 6. Carbon Dioxide in Cerebral Extracellular Fluids.- 7. Acid-Base and Energy Metabolism of the Brain in Hypercapnia and Hypocapnia.- V Adaption to Carbon Dioxide.- 1. Metabolic Aspects of Adaptation to Carbon Dioxide.- 2. Acid-Base Equilibrium in Chronic Hypercapnia.- 3. The Extracellular Bicarbonate Concentration and the Regulation of Ventilation in Chronic Hypercapnia in Man.- 4. Respiratory Gas Exchange, Acid-Base Balance, and Electrolytes during and after Maximal Work Breathing 15 mm Hg PICo2.- 5. Adaptation to Hypocapnia and its Role in Adaptation to Hypoxia.- VI Mathematical Models for Carbon Dioxide Regulation.- 1. Regulation of the Carbon Dioxide of Arterial Blood by Ventilation.- 2. The Behavior of the Carbon Dioxide Stores of the Body during Unsteady States.- 3. Carbon Dioxide Stores in the Study of Energy Metabolism.- Author Index.