Cancer Neurology in Clinical Practice

This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life."This textbook is a valuable resource for medical oncologists and radiation oncologists, as well as neurologists and neuro-oncologists dealing with these patients. ... Overall, the chapters are well organized, clearly written, fairly balanced, and reasonably up to date. ... I would recommend it as a learning tool to physicians in training (medical students, residents, and fellows) and for more experienced physicians as both a review/ update and a way to gain more in-depth knowledge and insight into the neurologic problems of cancer patients." (John C. Flickinger, International Journal of Radiation Oncology Biology Physics, Vol. 73 (2), 2009)

"The general organization of the book is logical and facilitates its practical and everyday use. ... Overall this textbook is very comprehensive and encompasses main neuro-oncological challenges. ... Schiff, Kesari and Wen have edited a very elegant and highly practical textbook, written by recognized authorities in their respective fields, which will be used by a wide range of medical and surgical specialists who are confronted on a daily basis with neurological manifestations of cancer in their practice." (I. Radovanovic and G. Zadeh, British Journal of Cancer, Vol. 100 (6), 2009)

Autorentext

David Schiff, MD

Harrison Distinguished Teaching Professor of Neurology, Neurological Surgery, and Medicine

University of Virginia

Charlottesville, VA

USA

Isabel Arrillaga, MD, PhD

Instructor, Harvard Medical School;

Massachusetts General Hospital

Department of Neurology/Neuro-Oncology

Boston, MA

USA

Patrick Y. Wen, MD

Professor of Neurology, Harvard Medical School; Dana-Farber/Brigham and Women's Cancer Center, Center for Neuro-Oncology

Boston, MA

USA

Inhalt

Part I: Overview

1: The Prevalence and Impact of Neurological Disease in Cancer

Part II: Diagnostic Studies

2: Imaging Neurologic Manifestations of Oncologic Disease

3: Other Diagnostic Tools for Neurological Disease in Cancer: EEG, EMG, and Lumbar Puncture

Part III: Nervous System Involvement of Systemic Cancers

4: Brain Metastasis as Complication of Systemic Cancers

5: Leptomeningeal Metastasis as Complication of Systemic Cancers

6: Spinal Metastasis as Complication of Systemic Cancers

7: Peripheral Nervous System Metastases as Complications of Systemic Cancers Part IV: Neurological Complications of Cancer

8: Headache as Complication of Cancer

9: Seizures as Complications in Cancer

10: Cerebrovascular Complications of Cancer

11: Elevated Intracranial Pressure and Hydrocephalus in Brain Tumor Patients

12: Cognitive Dysfunction, Mood Disorders, and Fatigue as Complications of Cancer

13: Paraneoplastic Syndromes of the Nervous System as Complications of Cancer

Part V: Neurological Complications of Cancer Therapy

14: Neurologic Complications of Radiation Therapy

15: Neurological Complications of Chemotherapy

16: Neurological Complications of Targeted Therapies

17: Neurological Complications of Immune-Based Therapies

18: Neurological Complications of Hematopoietic Stem Cell Transplantation

19: Neurologic Complications of Corticosteroids in Cancer Therapy

20: Central Nervous System Infections in Patients Receiving Cancer Therapies

Part VI: Neurological Complications of Specific Malignancies

21: Neurological Complications of Primary Brain Tumors

22: Neurological Complications of Lung Cancer

23: Neurological Complications of Breast Cancer and Its Treatment

24: Neurological Complications of Gastrointestinal Cancer

25: Neurologic Complications of Genitourinary Cancer 26: Neurologic Complications of Female Reproductive Tract Cancers

27: Neurological Complications of Sarcomas

28: Neurological Complications of Head and Neck Cancer

29: Neurological Complications of Malignant Melanoma

30: Neurological Complications of Leukemia

31: Neurologic Complications of Lymphoma

32: Neurologic Complications of Plasma Cell Dyscrasias

33: Neurologic Complications of Pediatric Systemic Cancer

Part VII: Neurological Complications in Long Term Cancer Survivors

34: Neurological Complications of Cancer and Cancer Therapies in Long Term Survivors