These are the Proceedings of the 2nd International Metastasis Congress of the Metastasis Research Society which took place in the town hall (Stadthalle) of Heidelberg, FRG, in September, 1988. This first Metastasis Congress in the FRG was organized in conjunction with the German Association of Cancer Research (SEK) of the German Cancer Society. The congress topic generated tremendous interest and attracted about 400 scientists from 22 countries. Most participants came from Europe, Israel, and the United States. Why did we organize the Metastasis Congress? Only about 50% of all people who develop some form of cancer are curable. Despite improved patient care and increasingly innovative and effective techniques for diagnosing and treating primary cancers, the development of secondary cancer colonies, i. e. , metastasis, can not be prevented and is the major cause of death. In the Federal Republic of Germany there are still as many as 160 000 cancer patients per year who succumb to their disease, often after periods of terrible suffering, and this overall figure is not improving. Partly because of the complexity of the process, basic research on metastasis has lagged behind other disciplines such as carcino­ genesis and cancer genetics. Metastasis formation involves the ability of malig­ nant cells to invade adjacent tissue and to penetrate into lymphatic or blood circulatory systems, or both, and to spread to near or distant sites to form new tumor colonies. Meanwhile, research on metastasis is receiving much attention.

Inhalt

Opening Plenary Lectures.- Metastasis: The Clinical Problem.- The Nude Mouse Model for Studies of Human Cancer Metastasis.- Symposium I: Genetic Control of Tumor Progression.- Tumor Cells Genetically Tagged with Transferred DNA Markers Reveal Evidence for Clonal Dominance of Primary Tumors by Metastatic Subpopulations.- Oncogenes and Tumor Progression: State of the Art.- Genetic Analysis of Invasive and Metastatic Capacity in T Lymphoma Cells.- Transforming Growth Factor-Beta: Possible Roles in Carcinogenesis.- Altered Gene Expression in Tumor Metastasis: The nm23 Gene.- Symposium II: Metastatic Phenotype and Cell Differentiation.- In Vivo Observations on Tumor Invasion.- Metastatic Phenotype and Cell Differentiation in Melanoma Cells.- Symposium III: Organotropism: Adhesion, Invasion, Angiogenesis, Homing, Growth Factors.- Adhesive, Invasive, and Growth Properties of Organ-Specific Metastatic Cells.- Importance of Cell Surface Carbohydrates in Tumor Cell Metastasis.- Cell Shape and the Metastatic Phenotype.- Cell Surface Plasminogen Activation.- Adhesion Mechanisms in Lymphoma Invasion and Metastasis.- The Role of Macrophages in the Regulation of Tumor Growth and Metastasis.- Symposium IV: Tumor Immunology.- The Influence of Murine and Human MHC Class I Expression on Tumor Growth and Metastasis.- Identification of Point Mutations in Genes Coding for turn-Antigens. A Step Towards the Understanding of Mouse and Human Tumor-Specific Transplantation Antigens?.- Recognition of the HLA Class II-Peptide Complex by T Cell Receptor: Reversal of MHC Restriction of a T Cell Clone by a Point Mutation in the Peptide Determinant.- Regulatory Aspects of the Anti-Tumor Immune Response.- Symposium V: Biological Tumor Therapy.- Active Specific Immunotherapy with Autologous Tumor Cell Vaccines Modified by Newcastle Disease Virus: Experimental and Clinical Studies.- The Effect of Interferon on Experimental Tumor Metastases.- Injections of Interleukins Around Tumor-Draining Lymph Nodes: A New Mode of Immunotherapy.- Autolymphocyte Therapy: An Outpatient, Low-Toxicity Approach to Adoptive Immunotherapy.- Active Specific Immunotherapy of Colorectal Cancer.- Review of Experience in Clinical Trials of Specific Active Tumor-Associated Antigen Immunotherapy of Lung Cancer.- Summary of Poster-Sessions and Minisymposia.- Metastasis: Growth and Pathogenesis, Models, and Mechanisms.- Metastasis: Diagnosis and Targeting, Genetic Changes.- Metastasis: Adhesion, Lectin-Carbohydrate Interaction, Organotropism, Growth Factors.- Invasion, Matrix Degradation, Angiogenesis, Motility.- Metastatic Phenotype and Cell Differentiation.- Microenvironmental Factors, Hormones, and Signal Transduction.- Tumor Immunology.- Immunotherapy Studies.- Therapy: Chemo-, Hormone- and Radiotherapy, Surgery.- Laudationes.- The First Paget-Ewing Award Ceremony and Laudatio for Professor Dale Rex Coman.- Laudatio for Professor Irwing Zeidman.- Satellite Workshop Clinical Perspectives for the Treatment of Metastases.- Session I Surgery, Radiotherapy, Chemotherapy, Hormonal Therapy.- Session II Bone Marrow Transplantation, Monoclonal Antibodies, Growth Factor Antagonists, Colony-Stimulating Factors.- Session III Adoptive Immunotherapy, Active Specific Immunotherapy, Biological Response Modifiers.