This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.

Zusammenfassung
Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.

Inhalt

Preface.-1 The regulation of a cell's Ca2+ signaling toolkit: the Ca2+ homeostasome.-2 Methods to detect Ca2+ in living cells.-3 Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs.-4 Two-photon calcium imaging in the intact brain.-5 Signaling through the Extracellular Calcium-Sensing Receptor (CaSR).-6 Ca2+ signaling: an outlook on the characterization of Ca2+ channels and their importance in cellular functions.-7 Ryanodine receptor calcium release channels: an evolutionary perspective.-8 Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.-9 Ryanodine Receptor Physiology and its role in Disease.-10 Phospholipase C.-11 Inositol 1,4,5-trisphosphate and its receptors.-12 Discovery and structural investigation of the IP3 receptor and the associated IRBIT, a personal account.-13 Pyridine nucleotide metabolites and calcium release from intracellular stores.-14 NAADP on target.-15 Store-operated Ca2+ entry.-16 Structure, regulation and biophysics of ICRAC, STIM/Orai1.-17 Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units.-18 Calcium around the Golgi apparatus: implications for intracellular membrane trafficking.-19 Calcium binding proteins.-20 Cytoplasmic calcium buffering.-21 Elementary calcium release events from the sarcoplasmic reticulum in the heart.-22 Calcium oscillations and pacemaking.-23 Calcium Oscillations and Waves in Cells.-24 Calcium signaling: From single channels to pathways.-25 Simulation strategies for calcium microdomains and calcium-regulated calcium channels.-26 Combined computational and experimental approaches to understanding the Ca2+ regulatory network in neurons.-27 7 nicotinic ACh receptors as a ligand-gated source of Ca2+ ions: the search for a Ca2+ optimum.-28 The Biology of Protein Kinase C.-29The role of C2 domains in PKC signaling.-30 Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the heart.-31 The role of molecular regulation and targeting in regulating calcium/calmodulin stimulated protein kinases.-32 Calcium sensors in exocytosis.-33 Regulation of voltage-gated calcium channels by synaptic proteins.-34 Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.-35 Calcium signalling in vascular smooth muscle cells: from physiology to pathology.-36 Calcium and endothelium-mediated vasodilator signaling.-37 Calcium signalling in cerebral vasoregulation.-38 Ca2+ Signaling Mechanisms in Bovine Adrenal Chromaffin cells.-39 Calcium stores in vertebrate photoreceptors.-40 Stem Cells and Calcium Signaling.-41 Calcium Signaling in Osteoclast Differentiation and Bone Resorption.-42 Calcium signaling in renal tubular cells.-43 Calcium in Epidermis.-44 Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels.-45 Proteinase-activated receptors (PARs) and calcium signalling in cancer.-46 Mechanosensory calcium signaling.-47 Role ca2+ in mechanisms of microrheology of the red blood cell changes.-48 Calcium imaging in the zebrafish.-49 Calcium signalling in xenopus oocyte.-50 Calcium oscillations, oocyte activation, and phospholipase C zeta.-51 Nuclear calcium signaling and its involvement in transcriptional regulation in plants.-52 Remodeling of Calcium Handling in Human Heart Failure.-53 Proarrhythmic Atrial Calcium Cycling in the Diseased Heart.-54 Neuronal Calcium Signaling and Alzheimer's Disease.-55 Voltage-gated Ca2+ channel mediated Ca2+ influx in epileptogenesis. Index.