This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.

The chapter "Calcium Signaling: From Basic to Bedside" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Inhalt

Preface

Calcium signaling: from basics to bedside

Md. Shahidul Islam

Measuring Ca2+ in living cells Joseph Bruton, Arthur J Cheng & Håkan Westerblad

High-throughput fluorescence assays for Ion Channels and GPCRs

Irina Vetter, David Carter, John Bassett, Jennifer R. Deuis, Bryan Tay, Sina Jami, Samuel D. Robinson.

Imaging Native Calcium Currents in Brain Slices

Karima Ait Ouares, Nadia Jaafari, Nicola Kuczewski and Marco Canepari

Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions.

Luca Hegeds, Boglárka Zámbó, Katalin Pászty, Rita Padányi, Karolina Varga, John T. Penniston, Ágnes Enyedi

A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders

Aikaterini Britzolaki, Joseph Saurine, Benjamin Klocke, Pothitos M. Pitychoutis

Cytoplasmic Calcium Buffering: An Integrative Crosstalk Juan A. Gilabert

An update on calcium binding proteins

Jacobo Elíes, Matilde Yáñez, Thiago M.C. Pereira, José GilLongo, David A. MacDougall &

Manuel CamposToimil

Phospholipase C

Colin A. Bill and Charlotte M. Vines

New insights in the IP3 receptor and its regulation

Jan B. PARYS & Tim VERVLIET

Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans

Fabian Nordenskjöld, Björn Andersson, Md. Shahidul Islam.

Evolution of Excitation-Contraction Coupling John J. Mackrill and Holly A. Shiels

Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels

Naohiro Yamaguchi

Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side

Agustín Guerrero-Hernández, Víctor Hugo Sánchez-Vázquez, Ericka Martínez-Martínez,

Lizeth Sandoval-Vázquez, Norma C. Perez-Rosas, Rodrigo Lopez-Farias, Adan Dagnino-Acosta

Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores

Antony Galione and Kai-Ting Chuang

Calcium Signaling in the Heart

Derek A. Terrar

Molecular basis and regulation of store-operated calcium entry

Jose J Lopez, Isaac Jardin, Letizia Albarrán, Jose Sanchez-Collado, Carlos Cantonero, Gines M Salido, Tarik Smani and Juan A. Rosado

Structure and activation mechanisms of CRAC channels

Carmen Butorac, Adéla Krizova, Isabella Derler

Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells

Yong-Xiao Wang, Lan Wang, and Yun-Min Zheng

Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis

Javier Avila-Medina, Isabel Mayoral-Sanchez, Isabel Galeano-Otero, Pedro C. Redondo, Juan A. Rosado, Tarik Smani

Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels.

Giorgio Santoni, Maria Beatrice Morelli, Oliviero Marinelli, Massimo Nabissi, Matteo Santoni, Consuelo Amantini.

Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression.

Giorgio Santoni, Maria Beatrice Morelli, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli and Consuelo Amantini

Calcium channels and Calcium-regulated channels in human red blood cells Lars Kaestner, Anna Bogdano...