The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms.

This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book's mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies.

The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.

Autorentext
Brian A. Baldo (Retired)
AUA (Pharmacy); BSc(Hons); PhDFormerly:Head, Molecular Immunology UnitKolling Institute of Medical ResearchRoyal North Shore Hospital of Sydneyand University of SydneySydney, NSW, Australia Nghia H. Pham (Retired)MSc; PhDFormerly:Molecular Immunology UnitKolling Institute of Medical ResearchRoyal North Shore Hospital of Sydneyand University of SydneySydney, NSW, Australia

Inhalt

Preface to the second edition

Ch. 1. Adverse reactions to drugs and drug allergy.

Ch. 2. Classification and descriptions of allergic reactions to drugs

Ch. 3. Mechanisms of hypersensitivity

Ch. 4. Diagnosis of allergic reactions to drugs

Ch. 5. Beta-Lactam antibiotics

Ch. 6. Other antimicrobial drugs

Ch. 7. Drugs and other agents used in anesthesia and surgery

Ch. 8. Opioid analgesic drugs

Ch. 9. Nonsteroidal anti-inflammatory drugs

Ch. 10. Contrast media

Ch. 11. Corticosteroids

Ch. 12. Proton pump inhibitors

Ch. 13. Targeted drugs for cancer therapy. Approved monoclonal antibodies

Ch. 14. Non-targeted drugs for cancer therapy

Ch. 15. Other approved therapeutic monoclonal antibodies

Ch. 16. Other biologics

Ch. 17. Vaccines