Biomaterials for Cardiac Regeneration

This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.

This book also:

• Provides a valuable overview of the engineering of biomaterials for cardiac regeneration, including coverage of combined biomaterials and stem cells, as well as extracellular matrices
• Presents readers with multidisciplinary coverage of biomaterials for cardiac repair, including the role of extracellular matrix in cardiac development, whole-heart tissue engineering, and spatial and electrical factors regulating cardiac regeneration and assembly
• Provides a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine

Inhalt

The Role of Extracellular Matrix in Cardiac Development.- The Role of Embryonic and Differentiated Cells in Cardiac Development.- Spatial and Electrical Factors Regulating Cardiac Regeneration and Assembly.- Microenvironmental Control of Stem Cell Fate.- Matrix Therapies for Cell Support and Cardiac Repair.- Growth Factor Delivery Matrices for Cardiovascular Regeneration.- Whole-Heart Tissue Engineering: Use of Three Dimensional Matrix Scaffolds.- Immunological and Phenotypic Considerations in Supplementing Cardiac Biomaterials with Cells.- Imaging of the Biomaterial Structure and Function.- Autologous Bioengineered Heart Valves: An Update.- Safety, Regulatory and Ethical Issues of Human Studies.