Cell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area. Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, andmetabolism of glycoconjugates.

Autorentext

Dr. Kausik Chattopadhyay is an Associate Professor in the Department of Biological Sciences at the Indian Institute of Science Education and Research Mohali (IISER Mohali). He received his PhD degree in Biochemistry from the Calcutta University in 2004, and subsequently completed his post-doctoral research with Prof. Stanley G. Nathenson at the Department of Microbiology and Immunology at the Albert Einstein College of Medicine, Bronx, New York, USA. He joined IISER Mohali as an Assistant Professor in 2009, and became Associate Professor in 2014. His research interests focus on understanding the structure-function mechanisms of membrane-damaging, bacterial, pore-forming toxins, and their implications for the host-pathogen interaction processes and immunity. He received the prestigious National BioScience Award for Career Development for the year 2014, awarded by the Department of Biotechnology, Ministry of Science & Technology, Government of India for his work in this area.

Dr. Subhash C. Basu is an Emeritus Professor at the University of Notre Dame (UND), Department of Chemistry and Biochemistry and also the president of the CDDRF (Cancer Drug Delivery Research Foundation). He received his PhD degree in Biochemistry in 1966 from the University of Michigan and was a Helen Hay Whitney Research Fellow (1966-70) under Professor Saul Roseman at the Johns Hopkins University. He joined both the teaching and research faculty at the UND in 1970 and became a Full Professor and Chairman of the Biochemistry, Biophysics and Molecular Biology program in 1983. He was awarded a D.Sc. degree in Biochemistry from the University of Calcutta, India in 1976 . He received the Jacob Javits Neuroscience Research Award from NIH (1989-98), and the S. C. Roy Medal of Achievement Award from the University of Calcutta, India in 1990. He was elected to the prestigious Johns Hopkins Honor Society in 1995. He has been an elected fellow of the American Association for the Advancement of Sciences (FAAAS) since 1988. He received the NRI-2015 Award Trophy in the International Professional category from the respected India Times newspaper in April 2015.

Inhalt

- Part I Membrane Organization.- Status of membrane asymmetry in erythrocytes: role of spectrin.- Multiple roles, multiple adaptors: Dynein during cell cycle.- Changes in the nuclear envelope in laminopathies.- Part II Biophysics of Membrane Proteins and Cell Surface Macromolecules.- The effect of nanoparticles on the cluster-size distributions of activated EGFR measured with photobleaching image correlation spectroscopy.- Factors influencing the chaperone-like activity of major proteins of mammalian seminal plasma, equine HSP-1/2 and bovine PDC-109. Effect of membrane binding, pH and ionic strength.- Exploring the Mechanism of Viral Peptide-induced Membrane Fusion.- Amyloids are novel cell adhesive matrices.- The prospects of Cadherin-23 as a mediator of homophilic cell-cell adhesion.- Structural-Mechanical and Biochemical Functions of Classical Cadherins at Cellular Junctions: A review and some hypotheses.- Part III G-Protein Coupled Receptors: from Structure to Function.- Identification of Sphingolipid-binding Motif in G Protein-coupled Receptors.- Molecular Signatures of Cholesterol Interaction with Serotonin Receptors.- Part IV Cell Surface Macromolecules in Neurobiology.- Group I Metabotropic Glutamate Receptors (mGluRs): Ins and Outs.- Soluble Amyloid Precursor Protein : Friend or Foe?.- C. elegans locomotion: Finding Balance in Imbalance.- Part V Cell Surface Macromolecules: Infection, Immunity and Disease.- Induction of Apoptosis in Metastatic Breast Cancer Cells: XV. Down Regulation of DNA Polymerase-a-Helicase Complex (Replisomes) and Glyco-Genes.- Dynamic function of DPMS is essential for angiogenesis and cancer progression.- Benzothiophenes as potent analgesics against neuropathic pain.- PRR function of innate immune receptors in recognition of bacteria or bacterial ligands.- Structural basis and functional implications of the membrane pore-formation mechanisms of bacterial pore-forming toxins.- Abiraterone and Ionizing Radiation Alter the Sphingolipid Homeostasis in Prostate Cancer Cells.- A glycomic approach towards identification of signature molecules in CD34+ haematopoietic stem cells from umbilical cord blood.- Part VI Microbial Cell Surface.- Vitamin C: A natural inhibitor of cell wall functions and stress response in mycobacteria.- The Wrappers of the 1, 2-Propanediol Utilization Bacterial Microcompartments.- F-type lectin domains provenance, prevalence, properties, peculiarities and potential.