The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Autorentext
Andres Trostchansky is an associate professor of Biochemistry at the University de la Republica in Montevideo, Uruguay. He has received the Roberto Caldeyro Barcia Award in Biology.
Homero Rubbo is a professor in the department of Biochemistry at the University de la Republica in Montevideo, Uruguay.

Inhalt

Prelims

Structure, characterization and physicochemical properties of bioactive lipids

Chapter 1: Diffusion and transport of reactive species across cell membranes (Matias N. Möller, Ernesto Cuevasanta, Florencia Orrico, Ana C. Lopez, Leonor Thomson and Ana Denicola)

Chapter 2: Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometry (Priscilla Bento Matos Cruz Derogis, Adriano B. Chaves-Fillho, Sayuri Miyamoto)

Signaling cascades mediated by bioactive lipids

Chapter 3: Understanding Peroxisome Proliferator-Activated Receptors: from the structure to the regulatory actions on metabolism (María Lamas Bervejillo and Ana María Ferreira)

Chapter 4: Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation of Xanthine Oxidoreductase (Eric Kelley)

Chapter 5: Unfolded protein response: Cause or consequence of lipid and lipoprotein metabolism disturbances? (Bruno Araújo Serra Pinto, Lucas Martins França, Francisco Rafael Martins Laurindo and Antonio Marcus de Andrade Paes)

Bioactive lipids in inflammatory and cardiovascular diseases

Chapter 6: Arachidonic acid metabolism in macrophages: role of NADPH oxidases (M. Noel Alvarez and Lucia Gonzalez, Uruguay)

Chapter 7: Lipid Metabolism and Signaling in Platelet Function (Antonio Marcus de Andrade Paes, Renato Simões Gaspar, Eduardo Fuentes, Sergio Wehinger, Iván Palomo, Andrés Trostchansky)

Chapter 8: Dyslipidemia in ischemia/reperfusion injury (Tamara Mazo, Veronica D'Annunzio, Martin Donato, Virginia Perez, Tamara Zaobornyj, Ricardo J. Gelpi)

Chapter 9: Epicardial adipose tissue in cardiovascular disease (Gabriela Berg; Verónica Miksztowicz; Celina Morales; Magalí Barchuk)

Role of bioactive lipids in neurodegenerative diseases

Chapter 10: Bioactive Lipids and the gut-brain axis: diet as a modulator of bioactivity and diversity of lipids in the brain (Ana Ledo, Barbara S. Rocha and Joao Laranjinha)

Chapter 11: Nitroalkylation of a-synuclein by nitro-oleic acid: Implications for Parkinson s disease (Cecilia Chavarría, Andrés Trostchansky, Rosario Durán, Homero Rubbo and José M. Souza)

Chapter 12: Bioactive lipids in inflammation after central nervous system injury (Rubèn López-Vales and Samuel David)

Index