The expanded second edition of this important work provides an up-to-date and comprehensive overview of Behçet syndrome. New and updated chapters focus on recent advances in the areas of pathogenesis, the microbiome, genetics and epigenetics, clustering of symptoms, disease assessment and new treatment options. The book examines how these developments have changed the way physicians approach diagnosis, treatment, and management of Behçet patients. It also analyzes the wide variety of clinical manifestations of the disease including mucocutaneous lesions, intraocular inflammation, central nervous system involvement, deep vein thrombosis and other forms of major vascular disease. Building on the success of its predecessor, the Second Edition of Behçet Syndrome is an invaluable resource for physicians, residents, fellows, and graduate students in rheumatology, dermatology, ophthalmology, neurology, gastroenterology, and internal medicine.

Autorentext
Yusuf Yazici, MDClinical Associate Professor of MedicineNew York University School of MedicineNew York, NY, USA Gulen Hatemi, MDProfessor of MedicineIstanbul University - CerrahpaaIstanbul, Turkey Emire Seyahi, MD,Professor of MedicineIstanbul University - CerrahpaaIstanbul, Turkey Hasan Yazici, MDProfessor of MedicineAcademic HospitalIstanbul, Turkey 

Zusammenfassung
Behçet's Syndrome has seen great strides over the last two decades in the availability of new treatments and the understanding of underlying pathogenesis. Only 30 years ago the majority of particularly young men with Behçet's lost total eye sight, now only a minority do. This book covers the most recent developments in the basic and clinical aspects of Behçet's Syndrome. International authorities have collaborated to offer their diverse expert knowledge on the multiple affected organs and systems, including the skin, the eye, the brain, the lungs and not the least the gastrointestinal and the locomotor systems. A special chapter is devoted to juvenile disease. The definitive resource on Behçet's Syndrome, this book is well suited for rheumatologists, dermatologists, ophthalmologists, neurologists, and health professionals caring for Behçet's patients.

Inhalt
Chapter 1. Introduction.- Chapter 2. Disease Definition and Epidemiology.- Chapter 3. Skin Mucosa Involvement and the Pathergy Reaction.- Chapter 4. Eye Disease.- Chapter 5. Nervous System Disease.- Chapter 6. Lung Disease.- Chapter 7. Peripheral Vascular and Cardiac Disease.- Chapter 8. Locomotor System Disease.- Chapter 9. Gastrointestinal Involvement.- Chapter 10. Other Clinical Aspects.- Chapter 11. Pediatric Behçet's Syndrome.- Chapter 12. Histopathology.- Chapter 13. Behçet's Syndrome and Microbes.- Chapter 14. Thrombophilia in Behçet's Syndrome.- Chapter 15. Genetics and Epigenetics.- Chapter 16. Disease Mechanisms.- Chapter 17. Prognosis.- Chapter 18. Disease Assessment.- Chapter 19. Management.- Chapter 20. The Patient's View.- Chapter 21. Future Research Considerations.