Sleep and anesthesia seem so similar that the task of analyzing the neurological similarities and differences between the two is an obvious research postulate. Both involve the loss of consciousness, or the loss of awareness of external stimuli. Yet when we investigate further, key differences start to manifest themselves-anesthesia is drug-induced while sleep requires no external cause being only the most salient. Other fascinating questions crowd in too: do we dream while under anesthesia, and do we feel pain while sleeping? Examining neural activity associated with sleep and anesthesia can be effected at various levels, from the microscopic, single-neuron level right up to that of whole neural populations.

This book aims to reveal the underlying neural mechanisms of sleep and anesthesia by employing a range of experimental techniques and applying theoretical models of neural activity that predict the mechanisms related to both states. Of course, these models offer deeper insights if their assumptions and resulting data can be correlated to experimental findings, and it is these correlations that the book focuses on. As the outcome of workshops on anesthesia and sleep at the 2007 and 2009 Computational Neuroscience Conferences in Toronto and Berlin, the chapters lay out key theoretical issues as well as hot contemporary research topics. It also details experimental techniques on various spatial scales, such as fMRIand EEG-experiments on the macroscopic, and single-neuron and LFP measurements on the microscopic scale

Zusammenfassung

Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences between sleep and anesthesia? To answer these questions, we may take a look at the neural origin of both effects and the involved physiological pathways. In which way do they resemble? Moreover, we ask what are the detailed features of normal sleep and general anesthesia as applied during surgery and which features exist in both phenomena? If yes in which way?

To receive answers to these questions, it is necessary to consider several experimental techniques that reveal underlying neural mechanisms of sleep and anesthesia. Moreover, theoretical models of neural activity may model both phenomena and comes up with predictions or even theories on the underlying mechanisms. Such models may attack several different description levels, from the microscopic level of single neurons to the macroscopic level of neural populations. Such models may give deeper insight into the phenomena if their assumptions are based on experimental findings and their predictions can be compared to experimental results. This comparison step is essential for valuable theoretical models.

The book is motivated by two successful workshops on anesthesia and sleep organized

during the Computational Neuroscience Conferences in Toronto in 2007 and in Berlin 2009. It aims to cover all the previous aspects with a focus on the link to experimental findings. It elucidates important issues in theoretical models that at the same time reflect some current major research interests. Moreover it considers some diverse issues which are very important to get an overview of the fields. For instance, the book discusses not only neural activity in the brain but also the effects of general anesthesia on the cardio-vascular system and the spinal cord in the context of analgesia. In addition, it considers different experimental techniques on various spatial scales, such as fMRI and EEG-experiments on the macroscopic scale and single neuron and LFP-measurements on the microscopic scale.

In total all book chapters reveal aspects of the neural correlates of sleep and anesthesia motivated by experimental data. This focus on the neural mechanism in the light of experimental data is the common feature of the topics and the chapters. In addition, the book aims to clarify the shared physiological mechanisms of both phenomena, but also reveal their physiological differences.

Inhalt

Foreword: Computing the mind by Anthony Hudetz.- Preface by Axel Hutt.- 1. Sleep and Anesthesia: A Consideration of States, Traits, and Mechanisms by G. Mashour, University of Michigan.- 2. Modelling sleep and general anaesthesia by J. Sleigh, University of Auckland.- Section 1: Sleep.- 3. Quantitative Modeling of Sleep Dynamics by P. Robinson, University of Sydney.- 4. The fine structure of slow-wave sleep oscillations: from single neurons to large networks by A. Destexhe, CNRS Gif-sur-Yvette Paris.- 5. A population network model of neuronal and neurotransmitter interactions regulating sleep-wake behavior in rodent species by V. Booth, University of Michigan.- 6. Neural correlates of human NREM sleep oscillations by P. Maquet, University of Liege.- Section 2: Anesthesia.- 7. A mesoscopic modelling approach to anaesthetic action on brain electrical activity by D. Liley, Swinburne University of Technology.- 8. Progress in modeling EEG effects of general anesthesia: Biphasic response and hysteresis by A. Steyn-Ross, University of Waikato.- 9. EEG modeling in anesthesia: a new insight into mean-field approach for Delta activity generation.- by Behnam Molaee-Ardekani, University of Rennes.- 10. A neural population model of the bi-phasic EEG-power spectrum during general anaesthesia by A. Hutt, INRIA Nancy.- 11. In vivo-electrophysiology of anesthetic action by B. Rehberg-Kluge, Charite Humboldt University Berlin