The past decade has brought great advances in our understanding of the mechanisms underlying auditory pathologies. Molecular biology and genetics have primarily contributed to this enhanced understanding, which in turn has driven the design of novel rational therapeutic interventions. Auditory Trauma, Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.

Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.

Contents:

• Auditory Pathology: When Hearing Is Out of Balance Jochen Schacht

• Genetics of Hearing Loss Ella Shalit and Karen B. Avraham

• Cochlear Homeostasis and Homeostatic Disorders Philine Wangemann

• Tinnitus: Theories, Mechanisms and Treatments Carol A. Bauer and Thomas J. Brozoski

• Autoimmune Inner Ear Disease Quinton Gopen, and Jeffrey P. Harris

• Age-Related Hearing loss and Its Cellular and Molecular Bases Kevin K. Ohlemiller and Robert D. Frisina

• The Patterns and Mechanisms of Noise-Induced Cochlear Pathology Donald Henderson, Bohua Hu, and Eric Bielefeld

• Drug-Induced Hearing Loss Leonard P. Rybak, Andrea E. Talaska, and Jochen Schacht

• Central Consequences of Cochlear Trauma D. Kent Morest andSteven J. Potashner

• Cell Death and Cochlear Protection Steven Green, Richard A. Altschuler, and Josef M. Miller

• Emerging Strategies for Restoring the Cochlea Stefan Heller and Yehoash Raphael

  About the editors:

  Jochen Schacht is Professor and Director of the Kresge Hearing Research Institute, University of Michigan, Ann Arbor. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.

  About the series:

  The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

  Zusammenfassung
  The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.

  Inhalt
  Auditory Pathology: When Hearing is Out of Balance.- Genetics of Hearing Loss.- Cochlear Homeostasis and Homeostatic Disorders.- Tinnitus: Theories Mechanisms and Treatments.- Autoimmune Inner Ear Disease.- Age-Related Hearing Loss and Its Cellular and Molecular Bases.- Patterns and Mechanisms of Noise-Induced Cochlear Pathology.- Drug-Induced Hearing Loss.- Central Consequences of Cochlear Trauma.- Cell Death and Cochlear Protection.- Emerging Strategies for Restoring the Cochlea.