The International Workshop - Conference on Atherosclerosis was held at the University of Western Ontario, London, Ontario, Canada, September 1 - 3, 1975. This book does not represent in a strict sense the entire proceedings of the above Workshop - Conference, but does reflect largely the format and the essential content of the scientific sessions. Thus, each of the three Sections of the book is comprised of the summarized presentations either at the Plenary Sessions (Section I), Proffered Papers (Section II) or Workshops (Section III). Section I comprises all the presentations of the Plenary Session on September 1 and the first three presentations at the Plenary Session on the last day of the Conference (September 3). The remaining two addresses of the latter Session (Resume of Workshop - Conference and Closing Remarks) follow the Section III at the end of the book. Sections II and III are subdivided into Chapters which correspond to the individual Sessions of Proffered Papers and Workshops, respectively. To facilitate the orientation, particularly for those who attended the Workshop - Conference, a Summary Table of all Sessions of Proffered Papers designated as Chapters in this book, precedes Section II, and a similar Summary Table of Workshops, also designated as Chapters, precedes Section III. The Tables include, in addition, the names of both Chairmen of each Session. The Chairmen whose names do not appear on either Summary Table are those who chaired the two Plenary Sessions, i. e.

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Welcoming Address.- A. Welcoming Address.- B. Introduction.- C. Section I (Plenary Sessions).- 1. Highlights of Current Research in Atherosclerosis.- 2. Plasma Lipoproteins: Recent Developments.- 3. Arterial Endothelium and Its Potentials.- 4. The Coronary Drug Project - Findings with Regard to Estrogen, Dextrothyroxine, Clofibrate and Niacin.- 5. The Place of the Aorto-Coronary By-Pass Surgery in the Treatment of Ischemic Heart Disease.- 6. Current Concepts of Coronary Thrombosis as Related to Atherosclerosis and Myocardial Infarction.- 7. Effect of Drugs on Platelets and Complications of Vascular Disease.- D. Section II (Proffered Papers) - Chapter 1 - Clinical Epidemiology.- 1. Hyperlipoproteinemia in Chronic Hemodialysis Patients and Long-Term Renal Transplant Recipients.- 2. Cholesterol Tracking; Prediction Over Time of Serum Cholesterol in Evans County, Ga..- 3. Coronary Heart Disease Profile in Australian Men and Some Factors Influencing Survival.- 4. Exercise ST Segment Depressions in Asymptomatic Hyperlipoproteinaemia and its Relation to Various Lipoprotein Classes.- 5. Atherosclerotic Cardiovascular Mortality in the Island of Crete Study.- 2 - Myocardial Infarction.- 1. Non-Obstructive Mural Coronary Thrombosis in Sudden Death.- 2. Improved Biochemical Detection of Myocardial Ischemic Injury.- 3. Myocardial Perfusion Assessed by Direct Coronary Arterial Injection of Radiolabelled Particles.- 4. Controlled Trial of a Cardiac Ambulance Service Manned by Ambulance Personnel.- 5. The Heparin Neutralizing Activity Test in the Diagnosis of Acute Myocardial Infarction (MI).- 3 - Fate of Lipoproteins.- 1. Chylomicron Remnant Particle Formation In Vivo in Hepatectomized Rat.- 2. Use of Esterified Retinol to Trace the Degradation of Chylomicrons in Cholesterol-Fed Rabbits.- 3. Postheparin Plasma Lipoprotein Lipase and Hepatic Lipase in Normal Human Subjects: Relationship to Age, Sex and Triglyceride Metabolism.- 4. Lipoprotein Lipase and Hepatic Lipase Activity in Post-heparin Plasma of Patients with Hypertriglyceridemia.- 5. Autoimmune Hyperlipidemia in the Nephrotic Syndrome.- 4 - Aortic Glycosaminoglycans, Gangliosides and Glycolysis.- 1. Further Studies on Glycosaminoglycan - Lipoprotein Interactions.- 2. Interactions of Glycosaminglycans with Collagen and Elastin in Bovine Aorta.- 3. Structural Characterization of Gangliosides from Normal and Atherosclerotic Human Thoracic Aortas.- 4. Studies on the Role of Increased Arterial Glycolysis in Atherogenesis.- 5. Influence of Glycosaminoglycan Content on Diffusive Transport of Calcium and Water Across the In Vitro Artery Wall.- 5 - Hemodynamics.- 1. Interrelationship of Hypertension and Atherosclerosis in a Subhuman Primate Model.- 2. Altered Renal Flow in the Localization of Sudanophilic Lesion in Rabbit Aortas.- 3. The Hemodynamic Basis of Atherosclerosis.- 4. City-Wide Screening for Detection of Hypertension.- 6 - Hyperlipidemia in Man and Treatment.- 1. Lipid-Protein Proportionate and Disproportionate Varieties of Lipoproteinemia.- 2. Metabolic Effects of the Bile Acid Sequestrant Polidexide (SeeholexR) in Man.- 3. Colestipol Hydrochloride, a New Hypolipidemic Drug: A Two-Year Study - Summary.- 4. Dietary Influence on Molecular Distribution of Serum Lipoproteins in Subjects with Proven Coronary Artery Disease.- 5. The Educational Diagnosis in Nutrition Counseling for Serum Cholesterol Reduction.- 7 - Atherosclerosis and Childhood.- 1. Metabolic Response to Intralipid Infusions in the Neonatal Period.- 2. Serum Cholesterol and Triglyceride Levels in Children from a Biracial Community - The Bogalusa Heart Study.- 3. Identification and Management of the Child at Risk for Atherosclerosis.- 4. A Study of the Dose-Effect Relationship of Cholestyramine in Children with Familial Hypercholesterolemia.- 5. Hyperlipidaemia and Weight Gain After Maturity.- 8 - Fibrinolytic Activity; Platelets.- 1. Associations Between Fibrinolytic Activity and Other Variables in an Industrial Population.- 2. Effects of Aspirin and Sulfinpyrazone on Platelet Prostaglandin Synthesis.- 3. Increase in Platelet Factor 4-Like Activity in the Initial Stages of Atherosclerosis in Pigeons.- 4. Inhibition of Platelet Adherence to Damaged Vessel Wall by Drugs.- 5. Experimental Modification of Platelet Survival.- 9 - Permeability; Tissue Culture.- 1. Hyperreactive Arterial Endothelial Cells in Atherogenesis - Effect of Smooth Muscle Relaxants.- 2. The Effect of Moderate Increases in Serum Cholesterol on the Blood-Artery Cholesterol Transfer Barrier.- 3. Cholesterol Exchange: Evidence for a Role in Arterial Cholesterol Accumulation.- 4. Cholesterol Metabolism in Human Endothelial Cells in Culture.- 5. Effect of Lipoprotein on In Vitro Synthesis of DNA in Aortic Tissue.- 10 - Experimental Models of Hyperlipidemia.- 1. Comparison of Age Related Alterations in Arterial Sterol Accumulation, Blood Pressure and Cholesterol Balance in Spontaneously Atherosclerosis-Susceptible and Atherosclerosis-Resistant Pigeons.- 2. Hereditary Hyperlipidemia in Chickens - Model for Study of Toxic Oxidation Products Found in Significant Amounts in U.S.P. Cholesterol, Powdered Eggs and Milk.- 3. A Comparative Study of the Effect of Dietary Cholesterol on Plasma Lipoproteins in Nonhuman Primates.- 4. Lipoproteins and the In Vitro Study of Cholesterol Metabolism in Gerbils.- 5. A Circulating Inhibitor of Post-Heparin Plasma Lipolysis in the Type IV-V Hyperlipoproteinemia Induced in Green Lymphoma-Bearing Hamsters.- 11 - Experimental Hypercholesterolemia.- 1. Turnover of Cholesterol in Aorta of Rabbits Previously Fed a Cholesterol-Enriched Diet.- 2. Turnover and Aortic Uptake of Very Low Density Lipoproteins (VLDL) from Hypercholesteremic Rabbits: Effect of Metformin.- 3. Increased Oxygen Consumption in Cholesterol-Fed Rabbits.- 4. Effects of Dietary Proteins and Amino Acids on the Plasma Cholesterol Concentrations of Rabbits Fed Cholesterol-Free Diets.- 5. Serum and Aortic Lipids of Rats Fed Long-Term Equilibrate Diets Containing Various Alimentary Fats.- 12 - Lipid Composition and Metabolism in Man.- 1. The Characteristics of Human Plasma Lipoprotein Metabolism: Influence of Low Caloric Diet on Hyperlipidemia.- 2. Fatty Acid Composition of Adipose Tissue in Patients with Myocardial Infarction Compared with Subjects Free of Coronary Heart Disease.- 3. Cholesterol Synthesis and Uptake by Fat Cells in Familial Hypercholesterolemia.- 4. Effects of Caloric Res…