At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery, a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. The survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, and new chemical approaches to and possible new targets for chemotherapy. It also discusses, as essential background, the history of chemotherapy, the practical aspects of therapy, and the public health consequences of current problems in antimalarial chemotherapy.
Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Klappentext

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Inhalt

I. Introduction The Need for New Approaches to Antimalarial Chemotherapy Philip J. Rosenthal and Louis H. Miller The History of Antimalarial Drugs Steven R. Meshnick and Mary J. Dobson Transport and Trafficking in Plasmodium-Infected Red Cells Kasturi Haldar and Thomas Akompong The Plasmodium Food Vacuole Ritu Banerjee and Daniel E. Goldberg Clinical and Public Health Implications of Antimalarial Drug Resistance Piero L. Olliaro and Peter B. Bloland II. Established Antimalarial Drugs and Compounds Under Clinical Development Chloroquine and Other Quinoline Antimalarials Leann Tilley, Paul Loria, and Mick Foley 8-Aminoquinolines Ralf P. Brueckner, Colin Ohrt, J. Kevin Baird, and Wilbur K. Milhous Mechanisms of Quinoline Resistance Grant Dorsey, David A. Fidock, Thomas E. Wellems, and Philip J. Rosenthal Folate Antagonists and Mechanisms of Resistance Christopher V. Plowe Artemisinin and Its Derivatives Steven R. Meshnick. Atovaquone-Proguanil Combination, Akhil B. Vaidya The Antimalarial Drug Portfolio and Research Pipeline Piero L. Olliaro and Wilbur K. Milhous III. New Compounds, New Approaches, and New Targets Novel Quinoline Antimalarials Paul A. Stocks, Kaylene J. Raynes, and Stephen A. Ward New Antimalarial Trioxanes and Endoperoxides Gary H. Posner, Mikhail Krasavin, Michael McCutchen, Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias, and Michael H. Parker Antibiotics and the Plasmodial Plastid Organelle Barbara Clough and R. J. M. (Iain) Wilson Fresh Paradigms for Curative Antimetabolites Pradipsinh K. Rathod. Iron Chelators, Mark Loyevsky and Victor R. Gordeuk Protease Inhibitors Philip J. Rosenthal Inhibitors of Phospholipid Metabolism Henri Joseph Vial and Michèle Calas Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport Annette M. Gero and Alexander L. Weis