Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to ascertain their abilities to be used for industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability for production of medically and pharmaceutically important proteins, and the application of animal cells to gene therapy and artificial organs. This Volume gives the readers a complete review of the present state of the art in Japan. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working either in academic environments or in industries of biotechnology and pharmacy.

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Symposium 1. Role of Heparan Sulfate Proteoglycan in Cell Growth and Differentiation. Symposium 2. Glycoengineering. Symposium 3. Artificial Organ and Cell Therapy. Symposium 4. Immunological Manipulation. Symposium 5. DT40 Cells as a System of Homologous Gene Recombination. Symposium 6. Transgenic Livestock. Symposium 7. Transgenic Fish: Standardization of Technology in the Model System and Aquaculture. Symposium 8. Growth, Immortality and Death of Cells in Culture: Present and Future Impact for the Development of Health Care Products. Symposium 9. Gene Transfer to Cells and Tissues of Living Animals: Application to Production and Therapeutics. Oral Session. Cell Culture for Assessment of Physiologically Functional Substances. Expression of Recombinant Animal Genes in Cultured Animal Cells. Cell Culture Engineering. Cost Performance for Producing Biochemicals. Establishment of Functional Cell Lines for Production of Biologicals. Application of Human Monoclonal Antibody. Cell Characterization and Validation. Poster Session. Cell Culture Engineering. Expression of Recombinant Animal Genes in Cultured Animal Cells. Cell Characterization and Validation. Transplantation and Artificial Organs. Transgenic Technology. Antibody Technology. Cytokines and Signal Transduction. Cell Culture for Assessment of Physiologically Functional Substances. Author Index. Subject Index.