This volume covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections. There is a balance of clinical basic science. In response to numerous requests, additional tropical topics are covered in some depth. As before, the emphasis is on hot topics of clinical relevance delivered by world class speakers. TOC:Preface.- War, Infectious Disease and Poverty.- Future Prospects for the Drug Treatment of Malaria in Children.- New Malaria Vaccines.- The Most Neglected Diseases of Children.- Leishmaniasis.- Ebola, Lassa and Hantavirus.- Rotavirus and the Rationale for Prevention.- Development of the Immune System in the Neonate and Infant.- Controversies in Management of Neonatal Sepsis.- Advances in the Diagnosis of TB: Outbreaks in Neonates.- Chlamydial Infections in Children and Adolescents.- The Role of Pre- and Post-Natal Infection in Chronic Lung Disease and Prematurity.- Catheter-Related Infections.- Pathogenesis of Pneumococcal Infection.- Diagnosis and Prevention of Pneumococcal Infection.- Rational Antibiotic Treatment of Pneumonia in Children.- New Antibiotics for Gram Positive Infections.- Management Issues for HIV Infected Children.- Heterologous Effects of Vaccines.- Non-Tuberculous Mycobacterial Infection.- Kingella kingae: an Emerging Paediatric Pathogen.- How to Treat Acute Musculoskeletal Infections in Children.- Emergence and Management of Resistant Staphylococci.- Prevention of HIV Transmission to Children in Africa.- Practical Aspects of ART in Children.- Antibiotics for Childhood Otitis Media: Overused and Confused? -Otitis Media Management Debate.- Index.

Zusammenfassung
This book is based on the course Infection and Immunity in Children 2005 which was held at St Catherine's College Oxford, UK in June 2005. This is the third book in this series covering topics in infection and immunity during childhood and based on the Oxford courses. These courses, and their companion books, are aimed at encouraging excellence in clinical practice and raising the pro? le of paediatric infectious disease with a particular eye on the needs of trainees in the specialty. At the time of writing a fourth course is already at an advanced stage of planning for June 2006 with a completely new programme once again. You will ? nd in this book a wealth of state of the art information about various aspects of paediatric infectious diseases written by leading authorities in the ? eld. We hope this volume will bring new insights into the management of children with infectious diseases and improve the health of children. Andrew J Pollard and Adam Finn January 2006 v Acknowledgments We are indebted to all of the contributors to this text who have generously provided their carefully written manuscripts in good time for editing and publication. We are also grateful to the staff of St Catherine's College, Oxford, UK who hosted Infection and Immunity in Children 2005 on which the text is based.

Inhalt
Warfare and the State of the World's Children.- How Do We Treat Children with Severe Malaria?.- The Neglected Tropical Diseases: The Ancient Afflictions of Stigma and Poverty and the Prospects for their Control and Elimination.- Viral Haemorrhagic Fevers Caused by Lassa, Ebola and Marburg Viruses.- Rotavirus and Rotavirus Vaccines.- Transient Deficiencies of T-Cell-Mediated Immunity in the Neonate.- Controversies in Neonatal Sepsis: Immunomodulation in the Treatment and Prevention of Neonatal Sepsis.- Chlamydia trachomatis Genital Infection in Adolescents and Young Adults.- The Role of Inflammation and Infection in the Development of Chronic Lung Disease of Prematurity.- Streptococcus pneumoniae: Infection, Inflammation and Disease.- Impact of Antimicrobial Resistance on Therapy of Bacterial Pneumonia in Children.- Diagnosis and Prevention of Pneumococcal Disease.- New Antibiotics for Gram-Positive Infections.- Clinical Manifestations of Nontuberculous Mycobacteria.- Kingella kingae: An Emerging Pediatric Pathogen.- How to Treat Acute Musculoskeletal Infections in Children.- Prevention of Transmission of HIV-1 from Mothers to Infants in Africa.- Practical Aspects of Antiretroviral Treatment in Children.- Antibiotic Treatment for Acute Otitis Media in Children.- Antibiotic Prophylaxis for the Prevention of Recurrent Urinary Tract Infections in Children.- Human Metapneumovirus: An Important Cause of Acute Respiratory Illness.