This book covers one of the most important topics in modern biology: recombination. Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. The book summarizes all existing views on the topic and puts them into context. It contains in-depth and up-to-date analysis of the chapter topics, written by international experts.

Zusammenfassung

This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.

Inhalt
Genetics of Recombination in the Model Bacterium Escherichia Coli.- Homologous Recombination in Low dC + dG Gram-Positive Bacteria.- The Bacterial RecA Protein: Structure, Function, and Regulation.- Biochemistry of Eukaryotic Homologous Recombination.- DNA helicases in recombination.- Holliday Junction Resolution.- Replication forks and replication checkpoints in repair.- Sister chromatid recombination.- Mating-Type Switching in S. Pombe.- Multiple Mechanisms of Repairing Meganuclease-Induced Double-Strand DNA Breaks in Budding Yeast.- The Cell Biology of Mitotic Recombination in Saccharomyces Cerevisiae.- The cell biology of homologous recombination.- BRCA2: safeguarding the genome through homologous recombination.- Meiotic recombination.- Site-specific recombination.- V(D)J Recombination: Mechanism and Consequences.- Nonhomologous End-Joining: Mechanisms, Conservation and Relationship to Illegitimate Recombination.- Analytical methods from the perspective of method standardization.