This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.

Autorentext
Amit is DNA Forensics Professional, Entrepreneur, Engineer, Bioinformatician and an IEEE Volunteer. In 2005 he founded first Private DNA Testing Company Bio Axis DNA Research Centre (P) Ltd in Hyderabad, India with an US Collaborator. He has vast experience of training 1000+ Crime investigation officers and helped 750+ Criminal and non-criminal cases to reach justice by offering analytical services in his laboratory. His group also works extensively on Genetic Predisposition risk studies of cancers and has been helping many cancer patients from 2012 to fight and win the battle against cancer. Amit was member of IEEE Strategy Development and Environmental Assessment committee (SDEA) of IEEE MGA. He is senior member of IEEE and has been a very active IEEE Volunteer at Section, Council, Region, Technical Societies of Computational Intelligence and Engineering in Medicine and Biology and at IEEE MGA levels in several capacities. He has driven a number of IEEE Conferences, Conference leadership programs, Entrepreneurship development workshops, Innovation and Internship related events. Currently He is the Managing Director of BioAxis DNA Research Centre (P) Ltd and visiting Professor at SJB Research Foundation, IEEE MGA Nominations and Appointments committee member and Chairman of IEEE Hyderabad Section.Prof. Ajit K. Saxena has received his Ph.D. from Department of Anatomy in Cyotgenetics from Institute of Medical Sciences, B.H.U. in the year of 1990. During his Ph.D. he studied how anticancer drugs cause interference with normal development of the foetus and with special reference to the cause of abnormality during differentiation of male gonads which lead infertility including congenital anomalies. After receiving his Ph.D. degree he joined NIH funded Indo US project at AIIMS New Delhi; where he identified the role of novel antigen IL6 as a signal traducing agent in human glioblastoma. He also worked in various renowned Institutions of India and abroad including C.C.M.B., C.D.R.I., A.M.C., B.P.K.I.H.S. (Dharan, Nepal) and B.H.U.,Varanasi. Currently, he is working as a Professor and Head in the Department of Pathology/Lab Medicine specialized in Clinical Genetics in All India Institute of Medical Sciences, Patna. He also possess administrative responsibilities as Head of the Department in prestigious institutions of India & abroad. In addition he has also served his duties of Scientific Advisor to the Government. His research interest includes study of Gene Polymorphism in Congenital Neural Tube Defects/ Tumor Biology/Infertility and Cytokines gene expression in chronic wounds and hypertrophic scars. Currently, his research interest includes role of stem cells in translational research. Of course, Dr Saxena published more than 100 articles in peer reviewed journals of international reputes with high citations. Based on his research and fellowship training, he has received several Awards and Honours, such as Gold Medal Award, Confer 'Vivek Ratan Award' and Millennium Award, Health Care Excellence Award, Life Time Achievement Awards (three times). Besides his research, teaching and administration he has also guided postgraduate (Ph.D,MD,MS, MTech) students. He is serving as an editorial member of various reputed journals and reviewer for several government funded project and research papers. He also acquired and completed several Government funded research projects (ICMR, DBT, CSIR,DST). Dr Saxena is a fellow and member of various scientific organizations, National Academy of Sciences, USA, National Academy for advancement of science and technology (USA), member of National Academy of Medical Sciences, India. He is also a Fellow of Indian Association of Biomedical Scientist, Chennai, Fellow of Indian Association of Applied Biotechnology, Mysore. Currently he is engaged in the developing Advanced Clinical Genetics Laboratory for Diagnostic, Training and Research in India (Bihar).

Chris Gwo Giun Lee is an investigator in signal processing systems for multimedia and bioinformatics. His work on analytics of algorithm concurrently with architecture, Algorithm/Architecture Co-Design (AAC), has made possible accurate and efficient computations on SoC, cloud, and edge. His work has contributed to 130+ publications with the invention of 50+ patents globally. His AAC work resulted in industry deployment of 60+ million LCD panels worldwide. Two patents were licensed by the US health industry for the development of analytics platform based precision medicine products (Boston, MA, June 1, 2015, GLOBE NEWSWIRE). His work was pivotal in delivering international standards, e.g. and RVC & 3D HEVC in MPEG. Chris was a system architect in Philips Semiconductor, project leader in Silicon Valley, and was recruited to NCKU in 2003. He received BSEE from NTU, Taiwan, MSEE, and PHDEE from UMASS. Chris is AE for IEEE TSP and was AE for IEEE TCSVT and received Best AE Award in...

Inhalt

Introduction to COVID 19 and Novel Coronavirus 19

Current status of knowledge regarding the NCOV 19

Evolutionary study of the NCOV 19

Insilco Analysis of Genes and gene products

Identification strategies of Virulence / Foreign proteins

Antigenic region Prediction

Structural annotation of the peptides

Identification of Potential Drug Targets and Ideal Vaccine Candidates

Structure optimization of the Potential Lead molecules

Future Prospects and NCOV Prognostic Biomarkers