Willkommen, schön sind Sie da!
Logo Ex Libris

Alzheimer's Disease

  • E-Book (pdf)
  • 888 Seiten
(0) Erste Bewertung abgeben
Bewertungen
(0)
(0)
(0)
(0)
(0)
Alle Bewertungen ansehen
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average li... Weiterlesen
E-Books ganz einfach mit der kostenlosen Ex Libris-Reader-App lesen. Hier erhalten Sie Ihren Download-Link.
CHF 649.00
Download steht sofort bereit
Informationen zu E-Books
E-Books eignen sich auch für mobile Geräte (sehen Sie dazu die Anleitungen).
E-Books von Ex Libris sind mit Adobe DRM kopiergeschützt: Erfahren Sie mehr.
Weitere Informationen finden Sie hier.
Bestellung & Lieferung in eine Filiale möglich

Beschreibung

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research.
This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Autorentext

Khalid Iqbal is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.

Sangram S. Sisodia is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.

Bengt Winblad is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.



Klappentext
Alzheimer's Disease is an ever-present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume in the series:
  • Provides a uniques source of reference to the important work being done in this field
  • Gives academics and clinicians an opportunity to learn about cutting edge developments
  • Covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Inhalt

List of Contributors xii

Dedications xxvi

Scientists Honored for Pioneering Research xxix

Preface xxxv

Acknowledgments xxxvi

I. EPIDEMIOLOGY AND RISK FACTORS 1

1. The Transition from Normal Functioning to Dementia in the Aging Population 3
Laura Fratiglioni, Brent Small, Bengt Winblad and Lars Bäckman

2. Epidemiology of Alzheimer's Disease and Dementia: Advances and Challenges 11
Robert Katzman

3. Epidemiology of Dementia in Down's Syndrome 23
Nicole Schupf

II. GENETICS 31

4. A Genomic Search for Alzheimer's Disease Genes 33
Jonathan L. Haines, L. Renee Bailey, Janet M. Grubber, Dale Hedges, Jenifer L. Hall, Sandra West, Leonard Santoro, Beth Kemmerer, Anne M. Saunders, Allen D. Roses, Gary W. Small, William K. Scott, P. Michael Conneally, Jeffery M. Vance and Margaret A. Pericak-Vance

5. Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH-AD Genetics Initiative 45
Lars Bertram, Deborah Blacker, Adam S. Crystal, Jennifer Jones, Devon Keeney, Laura A. MacKenzie-Ingano, Kristina Mullin, Sanjay Basu, Stephen Yhu, Melvin McInnis, Rodney C. P. Go, Aleister J. Saunders and Rudolph E. Tanzi

6. Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene 53
Martin R. Farlow, Jill R. Murrell, Frederick W. Unverzagt, Michael Phillips, Masaki Takao, Christine Hulette and Bernardino Ghetti

7. Genetic Analysis of the Presenilin Pathway in Drosophila 61
Izhar Livne-Bar and Gabrielle L. Boulianne

8. Molecular Genetics and Transgenic Modeling of the Tauopathies 71
Jada Lewis, Matt Baker, Marjon Van Slegtenhorst and Mike Hutton

9. Regulation of Four-repeat tau Expression: Interactions between Exon and Intron Splicing Regulatory Sequences 87
Ian D'Souza and Gerard D. Schellenberg

III. DIAGNOSIS AND CLINICAL COURSE 97

10. Preclinical Prediction of AD: Relation Between Neuropsychological and Neuroimaging Findings 99
Marilyn S. Albert, Ronald J. Killiany, Keith Johnson, Rudolph E. Tanzi and Kenneth Jones

11. Neuropsychological Detection of Preclinical Alzheimer's Disease: Results of a Neuropathological Series of 'Normal' Controls 111
Kathleen A. Welsh-Bohmer, Christine Hulette, Donald Schmechel, James Burke and Ann Saunders

12. Potentially Reversible Conditions in Memory Clinic Patients 123
Anne-Mette Hejl, Peter Høgh and Gunhild Waldemar

13. The Alzheimer's Disease Centers' Neuropsychological Database Initiative: A Resource for Alzheimer's Disease Prevention Trials 129
Michael Grundman, Hyun T. Kim, David Salmon, Martha Storandt, Glenn Smith, Steven Ferris, Richard Mohs, Jason Brandt, Rachelle Doody, Kathleen Welsh-Bohmer, Judith Saxton, Kathy Saine, Frederick Schmitt, Paula Ogrocki, Nancy Johnson, Diane Howieson, Michelle Papka, Joanne Green, Anthony Gamst, Walter Kukull and Leon J. Thal, for the Alzheimer's Disease Centers' Neuropsychological Database Initiative

14. Mild Cognitive Impairment: Transition from Aging to Alzheimer's Disease 141
Ronald C. Petersen

15. Brain Functional Imaging in Early and Preclinical Alzheimer's Disease 153
Agneta Nordberg, Vesna Jelic, Eva Arnáiz, Bengt Långström and Ove Almkvist

16. Amyloid, PHF-tau, Ubiquitin and Synaptic Markers in the Progression of Alzheimer's Disease: Immunochemical Analyses of Frontal Cortex from Prospectively Studied Elderly Humans 165
D. S. Wang, E. Cochran, D. Bennett, E. Mufson, C. Eckman and D. W. Dickson

17. Imaging the Consequences of Alzheimer's Disease Pathology 181
Yaakov Stern and Scott Small

18. Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzheimer's Disease 193
Gary W. Small, Linda M. Ercoli, Daniel H.S. Silverman, S.-C. Huang, Susan Y. Bookheimer, Helen Lavretsky, Karen Miller, Prabha Siddarth, John C. Mazziotta, Ann M. Saunders, Margaret A. Pericak-Vance, Allen D. Roses, Jorge R. Barrio and Michael E. Phelps

19. Overview of...

Produktinformationen

Titel: Alzheimer's Disease
Untertitel: Advances in Etiology, Pathogenesis and Therapeutics
Editor:
EAN: 9780470851746
ISBN: 978-0-470-85174-6
Digitaler Kopierschutz: Adobe-DRM
Format: E-Book (pdf)
Herausgeber: Wiley
Genre: Klinische Fächer
Anzahl Seiten: 888
Veröffentlichung: 24.01.2003
Jahr: 2003
Untertitel: Englisch
Dateigrösse: 8.1 MB