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Alzheimer's Disease is an ever present problem affecting millions
of people around the world and, as people's average lifespan
lengthens, its prevalence is set to increase. A global effort is
needed to combat the disease, including research to investigate the
causes, development of effective treatments and, ultimately,
prevention of the disease. Published every two years, these timely
books discuss the very latest research.
This new volume provides a unique source of reference to the
important work being done in this field, it gives academics and
clinicians an opportunity to learn about cutting edge developments
and covers all aspects of Alzheimer's Disease, including diagnosis,
clinical course, epidemiological course and therapeutics and
disease mechanisms.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and
Therapeutics will provide essential information for basic and
clinical researchers in Alzheimer's Disease and other dementias as
well as for those who care for patients.
Autorentext
Khalid Iqbal is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.
Sangram S. Sisodia is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.
Bengt Winblad is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.
Zusammenfassung
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research.
This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
Inhalt
List of Contributors xii
Dedications xxvi
Scientists Honored for Pioneering Research xxix
Preface xxxv
Acknowledgments xxxvi
I. EPIDEMIOLOGY AND RISK FACTORS 1
The Transition from Normal Functioning to Dementia in the Aging Population 3
Laura Fratiglioni, Brent Small, Bengt Winblad and Lars Bäckman
Epidemiology of Alzheimer's Disease and Dementia: Advances and Challenges 11
Robert Katzman
Epidemiology of Dementia in Down's Syndrome 23
Nicole Schupf
II. GENETICS 31
A Genomic Search for Alzheimer's Disease Genes 33
Jonathan L. Haines, L. Renee Bailey, Janet M. Grubber, Dale Hedges, Jenifer L. Hall, Sandra West, Leonard Santoro, Beth Kemmerer, Anne M. Saunders, Allen D. Roses, Gary W. Small, William K. Scott, P. Michael Conneally, Jeffery M. Vance and Margaret A. Pericak-Vance
Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH-AD Genetics Initiative 45
Lars Bertram, Deborah Blacker, Adam S. Crystal, Jennifer Jones, Devon Keeney, Laura A. MacKenzie-Ingano, Kristina Mullin, Sanjay Basu, Stephen Yhu, Melvin McInnis, Rodney C. P. Go, Aleister J. Saunders and Rudolph E. Tanzi
Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene 53
Martin R. Farlow, Jill R. Murrell, Frederick W. Unverzagt, Michael Phillips, Masaki Takao, Christine Hulette and Bernardino Ghetti
Genetic Analysis of the Presenilin Pathway in Drosophila 61
Izhar Livne-Bar and Gabrielle L. Boulianne
Molecular Genetics and Transgenic Modeling of the Tauopathies 71
Jada Lewis, Matt Baker, Marjon Van Slegtenhorst and Mike Hutton
Regulation of Four-repeat tau Expression: Interactions between Exon and Intron Splicing Regulatory Sequences 87
Ian D'Souza and Gerard D. Schellenberg
III. DIAGNOSIS AND CLINICAL COURSE 97
Preclinical Prediction of AD: Relation Between Neuropsychological and Neuroimaging Findings 99
Marilyn S. Albert, Ronald J. Killiany, Keith Johnson, Rudolph E. Tanzi and Kenneth Jones
Neuropsychological Detection of Preclinical Alzheimer's Disease: Results of a Neuropathological Series of 'Normal' Controls 111
Kathleen A. Welsh-Bohmer, Christine Hulette, Donald Schmechel, James Burke and Ann Saunders
Potentially Reversible Conditions in Memory Clinic Patients 123
Anne-Mette Hejl, Peter Høgh and Gunhild Waldemar
The Alzheimer's Disease Centers' Neuropsychological Database Initiative: A Resource for Alzheimer's Disease Prevention Trials 129
Michael Grundman, Hyun T. Kim, David Salmon, Martha Storandt, Glenn Smith, Steven Ferris, Richard Mohs, Jason Brandt, Rachelle Doody, Kathleen Welsh-Bohmer, Judith Saxton, Kathy Saine, Frederick Schmitt, Paula Ogrocki, Nancy Johnson, Diane Howieson, Michelle Papka, Joanne Green, Anthony Gamst, Walter Kukull and Leon J. Thal, for the Alzheimer's Disease Centers' Neuropsychological Database Initiative
Mild Cognitive Impairment: Transition from Aging to Alzheimer's Disease 141
Ronald C. Petersen
Brain Functional Imaging in Early and Preclinical Alzheimer's Disease 153
Agneta Nordberg, Vesna Jelic, Eva Arnáiz, Bengt Långström and Ove Almkvist
Amyloid, PHF-tau, Ubiquitin and Synaptic Markers in the Progression of Alzheimer's Disease: Immunochemical Analyses of Frontal Cortex from Prospectively Studied Elderly Humans 165
D. S. Wang, E. Cochran, D. Bennett, E. Mufson, C. Eckman and D. W. Dickson
Imaging the Consequences of Alzheimer's Disease Pathology 181
Yaakov Stern and Scott Small
Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzheimer's Disease 193
Gary W. Small, Linda M. Ercoli, Daniel H.S. Silverman, S.-C. Huang, Susan Y. Bookheimer, Helen Lavretsky, Karen Miller, Prabha Siddarth, John C. Mazziotta, Ann M. Saunders, Margaret A. Pericak-Vance, Allen D. Roses, Jorge R. Barrio and Michael E. Phelps