This book presents the papers included in the proceedings of the 3rd International Conference of Advanced Computing and Informatics (ICACin'22) that was held in Casablanca, Morocco, on October 15-16, 2022. A total of 98 papers were submitted to the conference, but only 60 papers were accepted and published in this book with an acceptance rate of 61%. The book presents several hot research topics which include artificial intelligence and data science, big data analytics, Internet of Things (IoT) and smart cities, information security, cloud computing and networking, and computational informatics.