This book constitutes the refereed proceedings of the 4th International Conference on Advances in Quantitative Ethnography, ICQE 2022, held in Copenhagen, Denmark, during October 15-19, 2022.The 29 full papers included in this book were carefully reviewed and selected from 71 submissions. They were organized in topical sections as follows: QE Theory and Methodology Research; Applications in Education Contexts; and Applications in Interdisciplinary Contexts.