This book reports on the latest advancements of non-destructive testing and structural techniques as applied on a wide range of cultural heritage applications. Specifically, it covers relevant research on advanced sensing techniques and modern signal and image processing for diagnosis, redesign and health monitoring, applications of non-destructive assessment of the resilience of cultural heritage assets to climate change and natural hazards and digital non-destructive documentation techniques and methods for digital heritage. Based on contributions to the 4th International Conference on Transdisciplinary Multispectral Modelling and Cooperation for the Preservation of Cultural Heritage-Addressing World Challenges, TMM-CH2025, held on April 3-9, 2025, in Athens, Greece, thus, the book offers a timely reference for both academics and scientists, engineers, architects, archaeologists, conservators, geologists, art historians and interested stakeholders and public, as an initial source of recent scientific advancements on non-destructive techniques and technologies that are utilized for monitoring, documenting and preserving the world cultural heritage in a holistic approach.