This book constitutes the refereed proceedings of the 4th Brazilian Symposium on Bioinformatics, BSB 2009, held in Porto Alegre, Brazil, in July 2009

The 12 revised full papers and 6 extended abstracts were carefully reviewed and selected from 55 submissions. The papers are organized in topical sections on algorithmic approaches for molecular biology problems; micro-array analysis; machine learning methods for classification; and in silico simulation.

Inhalt

Algorithmic Approaches for Molecular Biology Problems.- Genotype Tagging with Limited Overfitting.- Constraint Programming Models for Transposition Distance Problem.- Comparison of Spectra in Unsequenced Species.- Micro-array Analysis.- BiHEA: A Hybrid Evolutionary Approach for Microarray Biclustering.- Using Supervised Complexity Measures in the Analysis of Cancer Gene Expression Data Sets.- Quantitative Improvements in cDNA Microarray Spot Segmentation.- Machine Learning Methods for Classification.- SOM-PORTRAIT: Identifying Non-coding RNAs Using Self-Organizing Maps.- Automatic Classification of Enzyme Family in Protein Annotation.- Representations for Evolutionary Algorithms Applied to Protein Structure Prediction Problem Using HP Model.- Comparing Methods for Multilabel Classification of Proteins Using Machine Learning Techniques.- Comparative Study of Classification Algorithms Using Molecular Descriptors in Toxicological DataBases.- In Silico Simulation.- Influence of Antigenic Mutations in Time Evolution of the Immune Memory - A Dynamic Modeling.- Short Papers.- FReDD: Supporting Mining Strategies through a Flexible-Receptor Docking Database.- A Wide Antimicrobial Peptides Search Method Using Fuzzy Modeling.- Identification of Proteins from Tuberculin Purified Protein Derivative (PPD) with Potential for TB Diagnosis Using Bioinformatics Analysis.- Mapping HIV-1 Subtype C gp120Epitopes Using a Bioinformatic Approach.- MHC: Peptide Analysis: Implications on the Immunogenicity of Hantaviruses' N protein.- An Ontology to Integrate Transcriptomics and Interatomics Data Involved in Gene Pathways of Genome Stability.