New and exciting concepts in the fields of adrenal physiology and pathophysiology have been emerging almost exponentially, producing a tremendous influx of new knowledge. In Adrenal Disorders, a panel of distinguished physicians and researchers-many active contributors to the discoveries-select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. A focused review of the molecular and cellular biology of the adrenal cortices medullae, coupled with a discussion of the secretion and metabolism of adrenal products, provide a sound physiological foundation for understanding the new approaches to adrenal disease.
Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.

Klappentext

In Adrenal Disorders, a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.

Inhalt

Part I. The Adrenal Gland: Physiology Ontogeny of the Hypothalamo-Pituitary-Adrenal Axis Michel Grino, Nadia Dakine, Odile Paulmyer-Lacroix, and Charles Oliver Adrenal Organogenesis and Steroidogenesis: Role of Nuclear Nuclear Receptor Steroidogenic Factor-1, DAX-1, and Estrogen Receptor Meera S. Ramayya Reappraisal of Adrenal Zonation Theories Based on the Differential Regulation of Apoptosis, G. W. Wolkersdörfer and Stefan R. Bornstein Pharmacology of Glucocorticoids: An Overview Achille Gravanis and Andrew N. Margioris Glucocorticoid Catabolism and the 11-Hydroxysteroid Dehydrogenase System Jonathan R. Seckl Androgens of Adrenal Origin George Mastorakos and Anthony G. Doufas Structure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory (StAR) Protein: Molecular Insights into the Acute Seroidogenic Response of the Adrenals and Gonads to Trophic Stimulation Caleb B. Kallen, Futoshi Arakane, Teruo Sugawara, Marianthi Kiriakidou, Staci E. Pollack, Hidemichi Watari, Lane K. Christenson, Michiko Watari, and Jerome F. Strauss III Regulation of Adrenocortical Function by the Sympathoadrenal System: Physiology and Pathology Monika Ehrhart-Bornstein and Stefan R. Bornstein Interleukin (IL)-1 Family of Cytokines and Corticotropin-Releasing Hormone (CRH) in the Adrenal Gland Andrew N. Margioris, Erene Dermitzaki, Maria Venihaki, and Achille Gravanis Part II. The Adrenal Gland: Pathophysiology Overview of Hyper- and Hypocortisolism W.W. de Herder and S.W.J. Lambert ACTH Resistance, Constantine Tsigos. Syndromes of Ectopic ACTH Secretion: Recent Pathophysiological Aspects Yves de Keyzer, Marie Laure Raffin-Sanson, Agnés Picon, and Xavier Bertagna Clinical Presentations and Diagnosis of Cushing's Syndrome Andrew N. Margioris and George P.Chrousos The Desmopressin Test: A New Tool in the Functional Evaluation of the Pituitary-Adrenal Axis Patients with Cushing's Syndrome S. Tsagarakis and N. Thalassinos PseudoCushing Syndromes Theodore Friedman Adrenocortical Tumors and Oncogenes Martin Reincke Management of Adrenal Cancer David E. Schteingart and Dominic Homan Adrenal Incidentalomas Bruno Allolio Congenital Adrenal Hyperplasia: 21-Hydroylase Deficiency Maria I. New Steroid 11-Hydroxylase Deficiency Perrin C. White Micronodular Adrenal Disease and the Syndrome of Myxomas, Spotty Skin Pigmentation, and Endocrine Overactivity Constantine A. Stratakis Congenital Lipoid Adrenal Hyperplasia Walter L. Miller Congenital Adrenal Hypoplasia Michael Peter and Wolfgang G. Sippell The HPA Axis and HIV Infection Daniel S. Donovan, Jr. and Robert G. Dluhy Hypothalamic-Pituitary-Adrenal Axis and Obesity Per Björntorp and Roland Rosmond Aldosterone Synthase Deficiency Michael Peter and Wolfgang G. Sippel Mineralocorticoid Excess Syndromes Richard D. Gordon Pheochromocytoma: Progress in Diagnosis, Therapy, and Genetics Karel Pacak, George P. Chrousos, Christian A. Koch, Jacques W. M. Lenders, and Graeme Eisenhofer