Gallopamil

Sinee the introduetion of Gallopamil in 1983 this drug has been applied in similar indications as Verapamil. Predominantly pat ients with stable or unstable angina peetoris, with hypertension, and hypertrophie eardiomyopathy have been treated. As far as ean be judged from preliminary clinieal experienee Gallopamil aehieves similar results as Verapamil with mueh lower doses. Instead of 3 times 160 mg Verapamil 2 to 3 times 50 mg Gallopamil ean be applied. Although the speetrum of side effects ofboth drugs is similar it is evident that oeeasionally patients ean tolerate one better than the other. Complaints about eonstipation may be less frequent with Gallopamil whereas stomaeh trouble may be more frequent. Frankfurt, August 1984 M. KALTENBACH R. HOPF v Table of Contents Gallopamil (D 600) - a Calcium Antagonist of High Potency and Specificity. Effects on the Myocardium and Pacemakers (A. FLECKENSTEIN, B. FLECKENSTEIN, F. SPÄH and Y. K. BYON). . . . . . . . . . . . . . . . . . . . . . . . 1 2 Blockade ofthe Ca + -dependent Bioelectrical Automaticity and Electromechanical Coupling of Smooth Musc1e Cells by Gallopamil (D 600) (G. FLECKENSTEIN-GRÜN and A. FLECKENS TEIN) . . . . . . . . . . . . . . . . . . . . . . . 33 Studies on the Mechanism of Action of D 600 on Isolated Myocytes (W. TRAUTWEIN and J. HESCHELER) . . . . . . . 49 Studies In Vitra and In Vivo on the Effect of Gallopamil on Coranary Vessels (A. G. B. Kov ACH, L. LIGETI, M. BAKOS, G. RUBANYI and A. KOLLER) . . . . . . . . . . . . . . . . . . 58 Electraphysiological Studies with Gallopamil on the Myocardium ofthe Human Ventric1e (H. NAWRATH and XIAN-GANG ZONG) . . . . . . . . . . . . . . . . . . . . . . .

Inhalt
Gallopamil (D 600) a Calcium Antagonist of High Potency and Specificity. Effects on the Myocardium and Pacemakers.- Blockade of the Ca2+-dependent Bioelectrical Automaticity and Electromechanical Coupling of Smooth Muscle Cells by Gallopamil (D 600).- Studies on the Mechanism of Action of D 600 on Isolated Myocytes.- Studies in Vitro and in Vivo on the Effect of Gallopamil on Coronary Vessels.- Electrophysiological Studies with Gallopamil on the Myocardium of the Human Ventricle.- Studies on the Cardiovascular Effects of Gallopamil.- Antihypoxic Effect of Gallopamil in the Brain.- Pharmacokinetics and Metabolism of Gallopamil.- The Effect of Gallopamil on the Haemodynamics of Patients with Coronary Heart Disease.- Pharmacodynamics and Electrophysiology of Gallopamil.- Anti-anginal Effect of the Calcium Antagonist Gallopamil.- Effect of Gallopamil on Coronary Arteries and Haemodynamics.- Effect of Gallopamil (D 600) on the ECG During Exercise, in Coronary Heart Disease.- Anti-anginal Effect of Gallopamil as Compared with Nifedipine.- Results of an Open Multicentre Study with 455 Patients with Coronary Heart Disease, Treated with Gallopamil for 1 Year.- Acute and Long-term Effects of Gallopamil in Patients with Stable Angina Pectoris.