Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 2

The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis" presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications. Volume 2 covers the use of NHCs in the various types of metathesis reaction, polymerization, cyclization reactions, oxidation reactions, and carbonylation/carboxylation reactions.

Contenu

2.1 Alkene Metathesis
2.1.1 Historical Overview of N-Heterocyclic Carbenes in Alkene Metathesis
2.1.2 Ring-Closing Metathesis
2.1.3 Cross Metathesis
2.1.4 Enyne Metathesis
2.1.5 Alkene Metathesis Based Polymerization
2.2 Polymerization, Oligomerization, and Telomerization Involving N-Heterocyclic Carbenes as Ligands or Initiators
2.3 Cyclization Reactions
2.4 N-Heterocyclic Carbenes in Asymmetric Transition-Metal Catalysis
2.5 Transition-Metal-Catalyzed Oxidations
2.6 Carboxylation, Carbonylation, and Dehalogenation
2.7 Recyclable Systems
2.7.1 Biphasic Systems
2.7.2 Covalently Immobilized N-Heterocyclic Carbene Complexes
2.7.3 Catalytic Systems Featuring Ionically Tagged N-Heterocyclic Carbene Ligands
2.7.4 Flow Systems for N-Heterocyclic Carbene Catalysis
2.8 Recent Advances in N-Heterocyclic Carbene Organocatalysis