Plasmonic Sensors and their Applications

An application focused guide which throws light upon the most recent developments in this field enabling its use in diverse areas of applications including a brief theory of plasmonic sensors.

Auteur

*Adil Denizli, Professor and Head of Biochemistry Division, Department of Chemistry, Hacettepe University, Ankara, Turkey. His main research fields are molecular imprinting technologies, purification of biomolecules by chromatographic methods, detection of molecules by sensors, and production and application of polymers with different surface and bulk properties, shapes, and geometries. Professor Denizli is the author of more than 460 articles and numerous book chapters and holds two patents. He is a full member of the Turkish Academy of Sciences, and sits on the editorial boards of 25 journals.*

Texte du rabat

A practically-focused reference and guide on the use of plasmonic sensing as a faster and cheaper alternative to conventional sensing platforms

Plasmons, the collective oscillations of electrons occurring at the interface between any two materials, are sensitive to changes in dielectric properties near metal surfaces. Plasmonic sensors enable the real-time study of unique surface properties by monitoring the effect of the material interaction at the sensor surface. Plasmonic sensing techniques offer fast, label-free analysis, and hold advantages over labelling techniques such as ELISA (enzyme-linked immunosorbent assay). Plasmonic Sensors and their Applications examines the development and use of highly sensitive and selective plasmonic sensing platforms in chemistry, biotechnology, and medicine. Contributions by an international panel of experts provide timely and in-depth coverage of both real-world applications and academic research in the dynamic field. The authors describe advances in nanotechnology, polymer chemistry, and biomedicine, explore new and emerging applications of plasmonic sensing, discuss future trends and potential research directions, and more. This authoritative volume:

• Demonstrates why plasmonic sensing is a profitable method for easy and label-free analysis in real-time
• Covers a variety of applications of plasmonic sensors, such as disease diagnostics, vitamin detection, and detection of chemical and biological warfare agents
• Includes a brief introduction to the history and development of plasmonic sensors
• Provides concise theory and background for every application covered in the text Plasmonic Sensors and their Applications is an invaluable resource for analytical chemists, biochemists, biotechnologists, protein and surface chemists, and advanced students of biotechnology.

Résumé
Plasmonic Sensors and their Applications A practically-focused reference and guide on the use of plasmonic sensing as a faster and cheaper alternative to conventional sensing platforms Plasmons, the collective oscillations of electrons occurring at the interface between any two materials, are sensitive to changes in dielectric properties near metal surfaces. Plasmonic sensors enable the real-time study of unique surface properties by monitoring the effect of the material interaction at the sensor surface. Plasmonic sensing techniques offer fast, label-free analysis, and hold advantages over labelling techniques such as ELISA (enzyme-linked immunosorbent assay). Plasmonic Sensors and their Applications examines the development and use of highly sensitive and selective plasmonic sensing platforms in chemistry, biotechnology, and medicine. Contributions by an international panel of experts provide timely and in-depth coverage of both real-world applications and academic research in the dynamic field. The authors describe advances in nanotechnology, polymer chemistry, and biomedicine, explore new and emerging applications of plasmonic sensing, discuss future trends and potential research directions, and more. This authoritative volume:

• Demonstrates why plasmonic sensing is a profitable method for easy and label-free analysis in real-time
• Covers a variety of applications of plasmonic sensors, such as disease diagnostics, vitamin detection, and detection of chemical and biological warfare agents
• Includes a brief introduction to the history and development of plasmonic sensors
• Provides concise theory and background for every application covered in the text Plasmonic Sensors and their Applications is an invaluable resource for analytical chemists, biochemists, biotechnologists, protein and surface chemists, and advanced students of biotechnology.

Contenu
Preface xi

1 Deciphering Plasmonic Modality to Address Challenges in Disease Diagnostics **1
**Esma Derin, Özgecan Erdem, and Fatih Inci

1.1 Introduction 1

1.2 Surface Plasmon Polaritons 2

1.2.1 Excitation of the SPP 3

1.3 Surface Plasmon Resonance (SPR) 4

1.4 Localized Surface Plasmon Resonance (LPSR) 5

1.5 Raman Spectroscopy and SERS 7

1.6 Whispering Gallery Mode (WGM) 8

1.7 Fiber Cables Sensors 9

1.8 New Trends in Plasmonic Sensors for the Applications in Disease Diagnosis 11

1.8.1 Mobile Phone-Integrated Platforms 11

1.8.2 Smart Material Integration 12

1.8.3 Naked-Eye Detection 16

1.9 Outcomes and Conclusion 18

References 19

2 Nanosensors Based on Localized Surface Plasmon Resonance **23
**Deniz Umut Yildirim, Amir Ghobadi, and Ekmel Ozbay

2.1 Historical and Theoretical Background 23

2.2 Fabrication of Metal Nanostructures 29

2.3 Improving Detection Limit of LSPR Sensors 31

2.4 Integration of LSPR with Other Molecular Identification Techniques 34

2.4.1 Metal-Enhanced Fluorescence 34

2.4.2 Surface-Enhanced Raman Spectroscopy 37

2.4.3 Matrix-Assisted Laser Desorption Ionization Mass Spectroscopy 39

2.5 Practical Issues 39

2.6 Conclusions and Future Prospects 43

References 44

3 Highly Sensitive and Selective Plasmonic Sensing Platforms **55
**Yeeren Saylan and Adil Denizli

3.1 Introduction 55

3.2 What Is Highly Sensitive (Ultrasensitive)? 56

3.3 Plasmonic Sensing Platforms 56

3.4 Recent Applications 57

3.4.1 Medical Applications 57

3.4.2 Environmental Applications 61

3.5 Conclusion Remarks 67

References 67

4 Plasmonic Sensors for Detection of Chemical and Biological Warfare Agents **71
**Semra Akgönüllü, Yeeren Saylan, Nilay Bereli, Deniz Türkmen, Handan Yavuz, and Adil Denizli

4.1 Introduction 71

4.2 Sensors 72

4.2.1 Plasmonic-based Sensors 72

4.3 Biological Warfare Agents 72

4.3.1 Detection of Biological Warfare Agents 73

4.4 Chemical Warfare Agents 79

4.4.1 Detection of Chemical Warfare Agents 79

4.5 Conclusion and Future Perspective 81

References 82

5 A Plasmonic Sensing Platform Based on Molecularly Imprinted Polymers for Medical Applications **87
**Neslihan Idil, Monireh Bakhshpour, Sevgi Aslyüce, Adil Denizli, and Bo Mattiasson

5.1 Introduction 87

5.2 Molecular Imprinting Technology 88

5.3 Plasmonic Sensing 89

5.4 Medical Applications 91

5.4.1 Drug Detection Via MIP-based SPR Sensor 91

5.4.2 Hormone Detection Via MIP-based SPR Sensor 94

5.4.3 Microorganism and Virus Detection Via MIP-based SPR Sensor 95

5.4.4 Antibody Detection Via MIP-based SPR Sensor 96

5.4.5 Nucleic Acid Detection Via MIP-based SPR Sensor 97

5.4.6 Biomarker Detection Via MIP-based SPR Sensor 97

5.5 Conclusion 97

References 100

6 Magnetoplasmonic Nanosensors **103
**Recep Üzek, Esma Sari, and Arben Merkoçi

6.1 Introduction 103

6.2 Synthesis 104

6.2.1 CoreShell or CoreSatellite 105

6.2.2 Heterodimers 107

6.2.3 Multicomponent Doped Hybrids 108

6.3 Biosensing Applications 109

6.3.1 Protein 109

6.3.2 Pathogens 111

6.3.3 DNA 112

6.4 Conclusion 113

Acknowledgments 114

References 114

7 Plasmonic Sensors for Vitamin Detection **121
***Duygu…